HCSGD entry for ITPR2

1. General information

Official gene symbolITPR2
Entrez ID3709
Gene full nameinositol 1,4,5-trisphosphate receptor, type 2
Other gene symbolsIP3R2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIDAbiological_process
GO:0005220Inositol 1,4,5-trisphosphate-sensitive calcium-release channel activityIEAmolecular_function
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006810TransportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0015085Calcium ion transmembrane transporter activityTASmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0030168Platelet activationTASbiological_process
GO:0031095Platelet dense tubular network membraneTAScellular_component
GO:0033017Sarcoplasmic reticulum membraneIMPcellular_component
GO:0035091Phosphatidylinositol bindingIEAmolecular_function
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0043235Receptor complexIDAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0071320Cellular response to cAMPIEAbiological_process
GO:0071361Cellular response to ethanolIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02588348470.93500159950.37654834441.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0265487456
GSE13712_SHEARDown-0.5651869656
GSE13712_STATICDown-0.0863899562
GSE19018Up0.0817338505
GSE19899_A1Up0.1652645119
GSE19899_A2Up0.9601562659
PubMed_21979375_A1Up1.0411735170
PubMed_21979375_A2Up0.9241354709
GSE35957Up0.0206639618
GSE36640Up0.3611305109
GSE54402Up0.6214626817
GSE9593Up0.2145448289
GSE43922Up1.1033583837
GSE24585Down-0.0253116622
GSE37065Up0.2503251580
GSE28863_A1Down-0.1973777729
GSE28863_A2Up0.2137345339
GSE28863_A3Down-0.2141548837
GSE28863_A4Down-0.0171577223
GSE48662Up0.2270127691

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016967MicroarrayFunctional MTI (Weak)18185580
hsa-miR-935MIMAT0004978MIRT036656CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT036984CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043084CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.