HCSGD entry for ITPR1
1. General information
| Official gene symbol | ITPR1 |
|---|---|
| Entrez ID | 3708 |
| Gene full name | inositol 1,4,5-trisphosphate receptor, type 1 |
| Other gene symbols | INSP3R1 IP3R IP3R1 SCA15 SCA16 SCA29 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IDA | biological_process |
| GO:0005218 | Intracellular ligand-gated calcium channel activity | ISS | molecular_function |
| GO:0005220 | Inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | IEA ISS TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005637 | Nuclear inner membrane | IEA | cellular_component |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA NAS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005955 | Calcineurin complex | IEA | cellular_component |
| GO:0006112 | Energy reserve metabolic process | TAS | biological_process |
| GO:0006816 | Calcium ion transport | NAS | biological_process |
| GO:0007165 | Signal transduction | NAS TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007202 | Activation of phospholipase C activity | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0014069 | Postsynaptic density | IEA | cellular_component |
| GO:0015085 | Calcium ion transmembrane transporter activity | TAS | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016529 | Sarcoplasmic reticulum | IEA | cellular_component |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0031088 | Platelet dense granule membrane | IDA | cellular_component |
| GO:0031094 | Platelet dense tubular network | IDA | cellular_component |
| GO:0031095 | Platelet dense tubular network membrane | TAS | cellular_component |
| GO:0032469 | Endoplasmic reticulum calcium ion homeostasis | IEA | biological_process |
| GO:0035091 | Phosphatidylinositol binding | ISS | molecular_function |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048016 | Inositol phosphate-mediated signaling | ISS TAS | biological_process |
| GO:0050796 | Regulation of insulin secretion | TAS | biological_process |
| GO:0050882 | Voluntary musculoskeletal movement | IEA | biological_process |
| GO:0051209 | Release of sequestered calcium ion into cytosol | ISS | biological_process |
| GO:0070059 | Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0711230766 | 0.3959812469 | 0.5690062310 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0598127578 |
| GSE13712_SHEAR | Down | -0.9192222368 |
| GSE13712_STATIC | Down | -0.3956550970 |
| GSE19018 | Down | -0.7340601713 |
| GSE19899_A1 | Up | 0.1132297206 |
| GSE19899_A2 | Down | -0.0952812791 |
| PubMed_21979375_A1 | Up | 0.8008254260 |
| PubMed_21979375_A2 | Up | 0.6551288905 |
| GSE35957 | Down | -0.3949794540 |
| GSE36640 | Up | 0.8594191136 |
| GSE54402 | Up | 0.4466587875 |
| GSE9593 | Up | 0.4828498118 |
| GSE43922 | Up | 0.7541238392 |
| GSE24585 | Up | 0.0639508227 |
| GSE37065 | Up | 0.6497274791 |
| GSE28863_A1 | Up | 0.0789226151 |
| GSE28863_A2 | Up | 0.0317971769 |
| GSE28863_A3 | Up | 0.1174060332 |
| GSE28863_A4 | Down | -0.0501816627 |
| GSE48662 | Down | -0.3936952128 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| D-Myo-Inositol-1,4,5-Triphosphate | DB03401 | EXPT01811 |
| Glycerol | DB04077 | EXPT01027 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-424-5p | MIMAT0001341 | MIRT003225 | Luciferase reporter assay | Non-Functional MTI | 20065103 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017604 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019619 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT022001 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028366 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
