HCSGD entry for ITPKB
1. General information
| Official gene symbol | ITPKB |
|---|---|
| Entrez ID | 3707 |
| Gene full name | inositol-trisphosphate 3-kinase B |
| Other gene symbols | IP3-3KB IP3K IP3K-B IP3KB PIG37 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | IEA | biological_process |
| GO:0008440 | Inositol-1,4,5-trisphosphate 3-kinase activity | IEA | molecular_function |
| GO:0043647 | Inositol phosphate metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045059 | Positive thymic T cell selection | IEA | biological_process |
| GO:0046579 | Positive regulation of Ras protein signal transduction | IEA | biological_process |
| GO:0046638 | Positive regulation of alpha-beta T cell differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5595614642 | 0.8370302990 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0085819550 |
| GSE13712_SHEAR | Down | -0.2520000128 |
| GSE13712_STATIC | Down | -0.3117774099 |
| GSE19018 | Down | -0.0080034247 |
| GSE19899_A1 | Down | -0.0041113181 |
| GSE19899_A2 | Down | -0.1319781135 |
| PubMed_21979375_A1 | Up | 0.2655204452 |
| PubMed_21979375_A2 | Up | 0.3470426075 |
| GSE35957 | Down | -0.1072323489 |
| GSE36640 | Down | -0.1070567240 |
| GSE54402 | Up | 0.0723853024 |
| GSE9593 | Up | 0.0162045512 |
| GSE43922 | Up | 0.0213315629 |
| GSE24585 | Down | -0.0353707387 |
| GSE37065 | Up | 0.0621347580 |
| GSE28863_A1 | Up | 0.2738538934 |
| GSE28863_A2 | Up | 0.4871201237 |
| GSE28863_A3 | Up | 0.0908379437 |
| GSE28863_A4 | Up | 0.0203830031 |
| GSE48662 | Up | 0.1711483523 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT045004 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047075 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
