HCSGD entry for ITPKA

1. General information

Official gene symbolITPKA
Entrez ID3706
Gene full nameinositol-trisphosphate 3-kinase A
Other gene symbolsIP3-3KA IP3KA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004683Calmodulin-dependent protein kinase activityIEAmolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006020Inositol metabolic processIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008440Inositol-1,4,5-trisphosphate 3-kinase activityIEAmolecular_function
GO:0030036Actin cytoskeleton organizationIEAbiological_process
GO:0043197Dendritic spineIEAcellular_component
GO:0043647Inositol phosphate metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0048167Regulation of synaptic plasticityIEAbiological_process
GO:0048365Rac GTPase bindingIEAmolecular_function
GO:0061003Positive regulation of dendritic spine morphogenesisIEAbiological_process
GO:0097062Dendritic spine maintenanceIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05626084880.97473607390.51543397151.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1583385814
GSE13712_SHEARUp0.3136864801
GSE13712_STATICUp0.0181615446
GSE19018Up0.1331029976
GSE19899_A1Up0.1752529399
GSE19899_A2Up0.3605414714
PubMed_21979375_A1Up0.0330857641
PubMed_21979375_A2Up0.4163573338
GSE35957Down-0.1303797567
GSE36640Up0.0569295356
GSE54402Up0.5110413794
GSE9593Down-0.0440761285
GSE43922Up0.4230409756
GSE24585Up0.2437820274
GSE37065Down-0.0894935438
GSE28863_A1Down-0.0718774775
GSE28863_A2Down-0.1525873591
GSE28863_A3Up0.4027320060
GSE28863_A4Up0.2079909839
GSE48662Up0.1673388409

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Inositol 1,3,4,5-TetrakisphosphateDB01863 EXPT01943 | DB03265
D-Myo-Inositol-1,4,5-TriphosphateDB03401 EXPT01811
Phosphoaminophosphonic Acid-Adenylate EsterDB04395 EXPT00524

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016467MicroarrayFunctional MTI (Weak)20304954
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.