HCSGD entry for ITK

1. General information

Official gene symbolITK
Entrez ID3702
Gene full nameIL2-inducible T-cell kinase
Other gene symbolsEMT LPFS1 LYK PSCTK2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001816Cytokine productionISSbiological_process
GO:0001865NK T cell differentiationIEAbiological_process
GO:0002250Adaptive immune responseISSbiological_process
GO:0004715Non-membrane spanning protein tyrosine kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006968Cellular defense responseTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007202Activation of phospholipase C activityISSbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationIDA TASbiological_process
GO:0032609Interferon-gamma productionIEAbiological_process
GO:0032633Interleukin-4 productionIEAbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042110T cell activationTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050852T cell receptor signaling pathwayISS TASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.72293327000.71079713160.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1040286373
GSE13712_SHEARUp0.2659578275
GSE13712_STATICDown-0.1299269365
GSE19018Up0.0263321875
GSE19899_A1Down-0.0212014450
GSE19899_A2Down-0.1573057702
PubMed_21979375_A1Up0.0641621967
PubMed_21979375_A2Down-0.0536357117
GSE35957Up0.0042252948
GSE36640Up0.1363932007
GSE54402Up0.0780203808
GSE9593Up0.0139510403
GSE43922Up0.0187253379
GSE24585Up0.1236795443
GSE37065Up0.1169319477
GSE28863_A1Down-0.1149628376
GSE28863_A2Up0.0021982168
GSE28863_A3Up0.1636975659
GSE28863_A4Down-0.0156634207
GSE48662Up0.0539496170

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

StaurosporineDB02010 EXPT02970 | EXPT02972
PazopanibDB06589 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.