HCSGD entry for ARAF
1. General information
| Official gene symbol | ARAF |
|---|---|
| Entrez ID | 369 |
| Gene full name | v-raf murine sarcoma 3611 viral oncogene homolog |
| Other gene symbols | A-RAF ARAF1 PKS2 RAFA1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | TAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005057 | Receptor signaling protein activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0032006 | Regulation of TOR signaling | IMP | biological_process |
| GO:0032434 | Regulation of proteasomal ubiquitin-dependent protein catabolic process | IMP | biological_process |
| GO:0033138 | Positive regulation of peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1994715778 | 0.9024944455 | 0.8620882652 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1495408977 |
| GSE13712_SHEAR | Up | 0.1002191131 |
| GSE13712_STATIC | Up | 0.3108052857 |
| GSE19018 | Down | -0.1912491470 |
| GSE19899_A1 | Down | -0.3018511645 |
| GSE19899_A2 | Up | 0.3333331024 |
| PubMed_21979375_A1 | Up | 0.0596018730 |
| PubMed_21979375_A2 | Up | 0.4453144026 |
| GSE35957 | Up | 0.2414680999 |
| GSE36640 | Up | 0.5964124418 |
| GSE54402 | Down | -0.0610568581 |
| GSE9593 | Down | -0.0043126237 |
| GSE43922 | Down | -0.0891350808 |
| GSE24585 | Up | 0.0372376172 |
| GSE37065 | Down | -0.1459807396 |
| GSE28863_A1 | Up | 0.1943882188 |
| GSE28863_A2 | Up | 0.1171326626 |
| GSE28863_A3 | Up | 0.2723036848 |
| GSE28863_A4 | Down | -0.0122269857 |
| GSE48662 | Up | 0.3083560182 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adenosine triphosphate | DB00171 | NUTR00017 | EXPT00007 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT004929 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT004929 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043358 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
