HCSGD entry for ITGB1

1. General information

Official gene symbolITGB1
Entrez ID3688
Gene full nameintegrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Other gene symbolsCD29 FNRB GPIIA MDF2 MSK12 VLA-BETA VLAB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0001618Virus receptor activityIEAmolecular_function
GO:0001669Acrosomal vesicleIEAcellular_component
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001708Cell fate specificationIEAbiological_process
GO:0001726RuffleTAScellular_component
GO:0001894Tissue homeostasisIEAbiological_process
GO:0001948Glycoprotein bindingIEAmolecular_function
GO:0001968Fibronectin bindingIEAmolecular_function
GO:0002020Protease bindingIEAmolecular_function
GO:0002042Cell migration involved in sprouting angiogenesisIEAbiological_process
GO:0003779Actin bindingIDA IEAmolecular_function
GO:0004872Receptor activityIEAmolecular_function
GO:0005178Integrin bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005518Collagen bindingIEAmolecular_function
GO:0005604Basement membraneIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005925Focal adhesionIDA IEAcellular_component
GO:0006874Cellular calcium ion homeostasisIEAbiological_process
GO:0006968Cellular defense responseTASbiological_process
GO:0007156Homophilic cell adhesionTASbiological_process
GO:0007159Leukocyte cell-cell adhesionIDAbiological_process
GO:0007160Cell-matrix adhesionIEA IMPbiological_process
GO:0007161Calcium-independent cell-matrix adhesionIGIbiological_process
GO:0007229Integrin-mediated signaling pathwayIEAbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008277Regulation of G-protein coupled receptor protein signaling pathwayIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0008305Integrin complexIEA NAScellular_component
GO:0008354Germ cell migrationIEAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0009986Cell surfaceIDAcellular_component
GO:0010811Positive regulation of cell-substrate adhesionIEAbiological_process
GO:0010976Positive regulation of neuron projection developmentIEAbiological_process
GO:0014704Intercalated discIEAcellular_component
GO:0014823Response to activityIEAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016477Cell migrationTASbiological_process
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0021943Formation of radial glial scaffoldsIEAbiological_process
GO:0030027LamellipodiumIEAcellular_component
GO:0030056HemidesmosomeIEAcellular_component
GO:0030175FilopodiumIDAcellular_component
GO:0030183B cell differentiationICbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030335Positive regulation of cell migrationIEAbiological_process
GO:0031175Neuron projection developmentIEAbiological_process
GO:0031345Negative regulation of cell projection organizationIEAbiological_process
GO:0031594Neuromuscular junctionIDA IEAcellular_component
GO:0032154Cleavage furrowIEAcellular_component
GO:0032587Ruffle membraneIDAcellular_component
GO:0032594Protein transport within lipid bilayerIEAbiological_process
GO:0033631Cell-cell adhesion mediated by integrinIEPbiological_process
GO:0034329Cell junction assemblyTASbiological_process
GO:0034667Alpha3-beta1 integrin complexIEAcellular_component
GO:0034677Alpha7-beta1 integrin complexIEAcellular_component
GO:0034678Alpha8-beta1 integrin complexTAScellular_component
GO:0034679Alpha9-beta1 integrin complexIEAcellular_component
GO:0034698Response to gonadotropinIEAbiological_process
GO:0035748Myelin sheath abaxonal regionIEAcellular_component
GO:0042277Peptide bindingIEAmolecular_function
GO:0042383SarcolemmaIDA IEAcellular_component
GO:0042470MelanosomeIEAcellular_component
GO:0042493Response to drugIEAbiological_process
GO:0043065Positive regulation of apoptotic processIGIbiological_process
GO:0043235Receptor complexIDAcellular_component
GO:0043236Laminin bindingIEAmolecular_function
GO:0043410Positive regulation of MAPK cascadeIEAbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045214Sarcomere organizationIEAbiological_process
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045807Positive regulation of endocytosisIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityNASmolecular_function
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0050776Regulation of immune responseTASbiological_process
GO:0050839Cell adhesion molecule bindingIPImolecular_function
GO:0050900Leukocyte migrationTASbiological_process
GO:0051393Alpha-actinin bindingIEAmolecular_function
GO:0051726Regulation of cell cycleIEAbiological_process
GO:0055007Cardiac muscle cell differentiationIEAbiological_process
GO:0055037Recycling endosomeIEAcellular_component
GO:0060135Maternal process involved in female pregnancyIEAbiological_process
GO:0070830Tight junction assemblyIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
GO:0071305Cellular response to vitamin DIEAbiological_process
GO:0071479Cellular response to ionizing radiationIEAbiological_process
GO:0071559Response to transforming growth factor betaIEAbiological_process
GO:2000811Negative regulation of anoikisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.68509195700.55992642380.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0273484674
GSE13712_SHEARUp0.0067473001
GSE13712_STATICUp0.1056583397
GSE19018Up0.1236408471
GSE19899_A1Up0.0684096176
GSE19899_A2Down-0.0477466378
PubMed_21979375_A1Down-0.4367994569
PubMed_21979375_A2Down-0.1102174000
GSE35957Up0.3233319635
GSE36640Up0.0419305387
GSE54402Up0.2182793840
GSE9593Up0.1531289669
GSE43922Up0.0479507463
GSE24585Down-0.0091934206
GSE37065Up0.1028181044
GSE28863_A1Down-0.1197412644
GSE28863_A2Down-0.4310776379
GSE28863_A3Down-0.3947108961
GSE28863_A4Up0.0046171051
GSE48662Up0.1160021468

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Anti-thymocyte Globulin (Rabbit)DB00098 BTD00040 | BIOD00040

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT002731MicroarrayFunctional MTI (Weak)15685193
hsa-miR-124-3pMIMAT0000422MIRT002731Immunoblot//Immunohistochemistry//qRT-PCR//Western blotFunctional MTI21196113
hsa-miR-124-3pMIMAT0000422MIRT002731Luciferase reporter assayFunctional MTI21112327
hsa-miR-124-3pMIMAT0000422MIRT002731MicroarrayFunctional MTI (Weak)18668037
hsa-miR-183-5pMIMAT0000261MIRT004015Immunoblot//Immunocytochemistry//Luciferase reporter assay//qRT-PCR//Reporter assay;OtherFunctional MTI19940135
hsa-miR-375MIMAT0000728MIRT019882qRT-PCR;MicroarrayFunctional MTI (Weak)20584986
hsa-miR-215-5pMIMAT0000272MIRT024365MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026513MicroarrayFunctional MTI (Weak)19074876
hsa-miR-9-3pMIMAT0000442MIRT035520Luciferase reporter assayFunctional MTI23530058
hsa-miR-769-5pMIMAT0003886MIRT039178CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT044978CLASHFunctional MTI (Weak)23622248
hsa-miR-25-3pMIMAT0000081MIRT050264CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 9 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

275790451, CD44H, CD29, and CD71 and lack of CD11b/c and CD45 markers
25922305Based on the production of ECM proteins, such as fibronectin, integrin beta1, and collagen type I; alkaline phosphatase (ALP) activity; and the expression of osteogenic genes, such as ALP, Runt-related transcription factor 2, and osteocalcin, cell sheets formed by PDLSCs derived from older donors demonstrated a less potent osteogenic capacity compared to those formed by PDLSCs from younger donors
21176525RESULTS: Flow cytometry results showed the detection rates for CD29, CD34 and CD45 were 97
20225285The expressions of CD166, CD49a, and CD106 decreased, whereas those of CD10, CD29, CD44, CD73, CD90, and CD105 showed no significant change
19940135Targeting of integrin beta1 and kinesin 2alpha by microRNA 183
19940135To gain insight into the biological roles of miR-183 we investigated two potential novel targets: integrin beta1 (ITGB1) and kinesin 2alpha (KIF2A)
19940135Targeting of the 3'-untranslated region (3'-UTR) of ITGB1 and KIF2A by miR-183 was confirmed by luciferase assay
19940135Transfection with miR-183 led to a significant decrease in cell invasion and migration capacities of HeLa cells that could be rescued by expression of ITGB1 lacking the 3'-UTR
19940135These effects were also rescued by expression of ITGB1 lacking the 3'-UTR
19940135The regulation of ITGB1 expression by miR-183 provides a new mechanism for the anti-metastatic role of miR-183 and suggests that this miRNA could influence the development and function in neurosensory organs, and contribute to functional alterations associated with cellular senescence in human diploid fibroblasts and human trabecular meshwork cells
17545049The expressions of CD29, CD44, and CD34 were observed in ASCs by flow cytometry while HLA-DR or CD133 expression was not detected
17371154Flow cytometric analysis indicated a strong need to investigate for novel cell-surface characteristic markers of BMSCs because there was no obvious difference in the expression of the selected characteristic BMSC cell surface markers CD29, CD44, CD90, CD105, and CD166 between fast-growing and slow-growing clones
16229018There was a high expression of CD90, CD29, CD44 and CD105 and variable and moderate expression of CD166 and CD106 at the start of MSC culture and at each passage during expansion
15263006We observed that the expression integrin beta(1) and focal adhesion kinase (FAK) were increased and that the phosphorylations of FAK and paxillin, hallmarks of focal adhesion formation, were also increased in senescent human diploid fibroblast cells
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