HCSGD entry for ITGAL

1. General information

Official gene symbolITGAL
Entrez ID3683
Gene full nameintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Other gene symbolsCD11A LFA-1 LFA1A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001772Immunological synapseIEAcellular_component
GO:0002291T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellIMPbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006928Cellular component movementTASbiological_process
GO:0006954Inflammatory responseNASbiological_process
GO:0007155Cell adhesionIEA NASbiological_process
GO:0007157Heterophilic cell-cell adhesionIMPbiological_process
GO:0007159Leukocyte cell-cell adhesionIEA IMPbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007166Cell surface receptor signaling pathwayIEAbiological_process
GO:0007229Integrin-mediated signaling pathwayIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008305Integrin complexNAScellular_component
GO:0009897External side of plasma membraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0022409Positive regulation of cell-cell adhesionIEAbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0042102Positive regulation of T cell proliferationIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0050776Regulation of immune responseTASbiological_process
GO:0050798Activated T cell proliferationIEAbiological_process
GO:0050839Cell adhesion molecule bindingIPImolecular_function
GO:0050850Positive regulation of calcium-mediated signalingIEAbiological_process
GO:0050900Leukocyte migrationTASbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.69792685690.74893400710.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0810077956
GSE13712_SHEARDown-0.2258512612
GSE13712_STATICUp0.0847972184
GSE19018Down-0.0070422208
GSE19899_A1Down-0.0127401322
GSE19899_A2Up0.0799792066
PubMed_21979375_A1Up0.2222386153
PubMed_21979375_A2Down-0.3617496796
GSE35957Up0.0255529029
GSE36640Up0.0056782043
GSE54402Up0.1107002391
GSE9593Up0.0189311339
GSE43922Up0.0509693545
GSE24585Up0.1239303542
GSE37065Up0.1211667869
GSE28863_A1Down-0.1726874464
GSE28863_A2Down-0.2119091702
GSE28863_A3Up0.3628058047
GSE28863_A4Up0.0037135698
GSE48662Down-0.0495282604

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

EfalizumabDB00095 BTD00074 | BIOD00074
Anti-thymocyte Globulin (Rabbit)DB00098 BTD00040 | BIOD00040
1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)PiperazineDB02177 EXPT01986
LFA703DB03932 EXPT00387
(S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDEDB04724 -
7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrileDB06972 -
3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)anilineDB07486 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.