HCSGD entry for ITGA5

1. General information

Official gene symbolITGA5
Entrez ID3678
Gene full nameintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Other gene symbolsCD49e FNRA VLA5A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisTASbiological_process
GO:0001726RuffleTAScellular_component
GO:0005154Epidermal growth factor receptor bindingIEAmolecular_function
GO:0005161Platelet-derived growth factor receptor bindingTASmolecular_function
GO:0005178Integrin bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0005925Focal adhesionIDAcellular_component
GO:0007044Cell-substrate junction assemblyIEAbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007157Heterophilic cell-cell adhesionIEAbiological_process
GO:0007159Leukocyte cell-cell adhesionIEAbiological_process
GO:0007229Integrin-mediated signaling pathwayIEAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007613MemoryIEAbiological_process
GO:0008305Integrin complexIEAcellular_component
GO:0009897External side of plasma membraneIEAcellular_component
GO:0010811Positive regulation of cell-substrate adhesionIEAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030335Positive regulation of cell migrationIEAbiological_process
GO:0030949Positive regulation of vascular endothelial growth factor receptor signaling pathwayTASbiological_process
GO:0032587Ruffle membraneIDAcellular_component
GO:0033631Cell-cell adhesion mediated by integrinIEAbiological_process
GO:0035313Wound healing, spreading of epidermal cellsIEPbiological_process
GO:0043184Vascular endothelial growth factor receptor 2 bindingTASmolecular_function
GO:0045202SynapseIEAcellular_component
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIMPbiological_process
GO:0050839Cell adhesion molecule bindingIEAmolecular_function
GO:0050900Leukocyte migrationTASbiological_process
GO:0071062Alphav-beta3 integrin-vitronectin complexTAScellular_component
GO:2000811Negative regulation of anoikisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02612895030.40728019830.37787917581.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6412204280
GSE13712_SHEARUp0.0916491593
GSE13712_STATICUp0.3860213191
GSE19018Down-0.1470329574
GSE19899_A1Up0.6046622699
GSE19899_A2Up0.2469583502
PubMed_21979375_A1Up1.0273879711
PubMed_21979375_A2Up2.3244357007
GSE35957Down-1.3171292038
GSE36640Down-0.0694903909
GSE54402Up0.2167649966
GSE9593Down-0.3455290974
GSE43922Up0.5536107763
GSE24585Up0.0854743112
GSE37065Up0.2377948070
GSE28863_A1Up0.7001209199
GSE28863_A2Up0.2879630618
GSE28863_A3Down-0.4564847573
GSE28863_A4Down-0.0559842459
GSE48662Down-0.1175898574

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-92a-3pMIMAT0000092MIRT003031Luciferase reporter assay//Western blot//MicroarrayFunctional MTI19460962
hsa-miR-31-5pMIMAT0000089MIRT004976Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19524507
hsa-miR-148b-3pMIMAT0000759MIRT007314Western blotFunctional MTI23238785
hsa-miR-98-5pMIMAT0000096MIRT027753MicroarrayFunctional MTI (Weak)19088304
hsa-miR-1229-3pMIMAT0005584MIRT036327CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042174CLASHFunctional MTI (Weak)23622248
hsa-miR-183-5pMIMAT0000261MIRT047079CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23238588The increase of these miRNAs during cells senescence was accompanied by a decrease in integrin alpha5 and collagen XVI expression at mRNA and/or protein levels resulting in reduced cellular adhesion and suggesting extracellular matrix remodeling
23238588These findings indicate that changes in miRNAs expression, by modulating the levels of adhesion proteins and extra-cellular matrix components, such as integrin alpha5 and collagen XVI, could contribute to the compositional remodelling of the dermis and epidermis occurring during skin aging
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