HCSGD entry for ITGA4
1. General information
| Official gene symbol | ITGA4 |
|---|---|
| Entrez ID | 3676 |
| Gene full name | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
| Other gene symbols | CD49D IA4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001968 | Fibronectin binding | IEA | molecular_function |
| GO:0001974 | Blood vessel remodeling | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0007157 | Heterophilic cell-cell adhesion | IEA | biological_process |
| GO:0007159 | Leukocyte cell-cell adhesion | IDA IEA | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | IEA | biological_process |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008305 | Integrin complex | IEA | cellular_component |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0016477 | Cell migration | IEA | biological_process |
| GO:0030183 | B cell differentiation | IC | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050776 | Regulation of immune response | TAS | biological_process |
| GO:0050839 | Cell adhesion molecule binding | IPI | molecular_function |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
| GO:0060324 | Face development | IEA | biological_process |
| GO:0060710 | Chorio-allantoic fusion | IEA | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
| GO:0090074 | Negative regulation of protein homodimerization activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9806927510 | 0.0000510505 | 0.9999902473 | 0.0115836207 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.4125654890 |
| GSE13712_SHEAR | Down | -1.3857888791 |
| GSE13712_STATIC | Down | -2.1059497732 |
| GSE19018 | Up | 0.2413038578 |
| GSE19899_A1 | Down | -0.9005824043 |
| GSE19899_A2 | Down | -3.8503498557 |
| PubMed_21979375_A1 | Down | -1.1602857093 |
| PubMed_21979375_A2 | Down | -2.8614003829 |
| GSE35957 | Up | 0.5267310341 |
| GSE36640 | Up | 0.4098931353 |
| GSE54402 | Down | -1.2120911077 |
| GSE9593 | Down | -0.6174851200 |
| GSE43922 | Down | -1.3963298545 |
| GSE24585 | Down | -0.6458449967 |
| GSE37065 | Down | -0.3037289341 |
| GSE28863_A1 | Down | -0.2898541268 |
| GSE28863_A2 | Down | -0.5794466508 |
| GSE28863_A3 | Down | -0.8375348826 |
| GSE28863_A4 | Down | -0.4399979448 |
| GSE48662 | Down | -0.1484172420 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Natalizumab | DB00108 | BTD00083 | BIOD00083 |
| ATL1102 | DB04997 | - |
| CDP323 | DB05092 | - |
| R1295 | DB05122 | - |
| R411 | DB05468 | - |
| MLN-02 | DB05802 | - |
| Tinzaparin | DB06822 | - |
| Vedolizumab | DB09033 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30c-5p | MIMAT0000244 | MIRT007135 | qRT-PCR | Functional MTI (Weak) | 23418453 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
