HCSGD entry for ITGA3

1. General information

Official gene symbolITGA3
Entrez ID3675
Gene full nameintegrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Other gene symbolsCD49C GAP-B3 GAPB3 ILNEB MSK18 VCA-2 VL3A VLA3a
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001764Neuron migrationIEAbiological_process
GO:0001968Fibronectin bindingIEAmolecular_function
GO:0005178Integrin bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005518Collagen bindingIEAmolecular_function
GO:0005886Plasma membraneIDA TAScellular_component
GO:0007155Cell adhesionIEAbiological_process
GO:0007160Cell-matrix adhesionTASbiological_process
GO:0007229Integrin-mediated signaling pathwayIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007613MemoryIEAbiological_process
GO:0008305Integrin complexIEA TAScellular_component
GO:0009986Cell surfaceIDAcellular_component
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0010634Positive regulation of epithelial cell migrationIEAbiological_process
GO:0010811Positive regulation of cell-substrate adhesionIEAbiological_process
GO:0010976Positive regulation of neuron projection developmentIEAbiological_process
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030426Growth coneIEAcellular_component
GO:0031345Negative regulation of cell projection organizationIEAbiological_process
GO:0034667Alpha3-beta1 integrin complexIEAcellular_component
GO:0034698Response to gonadotropinIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043235Receptor complexIDAcellular_component
GO:0043236Laminin bindingIEAmolecular_function
GO:0045202SynapseIEAcellular_component
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050900Leukocyte migrationTASbiological_process
GO:0060135Maternal process involved in female pregnancyIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00569745450.37123232780.19851176471.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2179022917
GSE13712_SHEARUp0.3442016122
GSE13712_STATICUp0.6949456846
GSE19018Up0.9727502128
GSE19899_A1Up0.1622561318
GSE19899_A2Up0.3012102859
PubMed_21979375_A1Down-0.2198427946
PubMed_21979375_A2Up0.9974335206
GSE35957Up0.6319813344
GSE36640Up0.4514291340
GSE54402Up0.3827943448
GSE9593Up1.6012637266
GSE43922Down-0.1750335413
GSE24585Up0.3417287197
GSE37065Up0.0584946663
GSE28863_A1Down-0.8226518875
GSE28863_A2Up0.0844455570
GSE28863_A3Down-0.9266574471
GSE28863_A4Up0.0811617420
GSE48662Up0.6530140207

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022979MicroarrayFunctional MTI (Weak)18668037
hsa-miR-1MIMAT0000416MIRT023953ProteomicsFunctional MTI (Weak)18668040
hsa-miR-26b-5pMIMAT0000083MIRT029991MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.