HCSGD entry for ITGA2

1. General information

Official gene symbolITGA2
Entrez ID3673
Gene full nameintegrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Other gene symbolsBR CD49B GPIa HPA-5 VLA-2 VLAA2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001618Virus receptor activityIEAmolecular_function
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001894Tissue homeostasisIEAbiological_process
GO:0002687Positive regulation of leukocyte migrationIEAbiological_process
GO:0005178Integrin bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005518Collagen bindingTASmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005925Focal adhesionIEAcellular_component
GO:0006928Cellular component movementIEAbiological_process
GO:0006971Hypotonic responseIEAbiological_process
GO:0007155Cell adhesionIEA TASbiological_process
GO:0007160Cell-matrix adhesionTASbiological_process
GO:0007229Integrin-mediated signaling pathwayIEAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0008305Integrin complexIEAcellular_component
GO:0009279Cell outer membraneIEAcellular_component
GO:0009887Organ morphogenesisTASbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0009986Cell surfaceIDAcellular_component
GO:0010634Positive regulation of epithelial cell migrationIEAbiological_process
GO:0010694Positive regulation of alkaline phosphatase activityIEAbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0014075Response to amineIEAbiological_process
GO:0014850Response to muscle activityIEAbiological_process
GO:0014911Positive regulation of smooth muscle cell migrationIEAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030879Mammary gland developmentIEAbiological_process
GO:0031346Positive regulation of cell projection organizationIEAbiological_process
GO:0032870Cellular response to hormone stimulusIEAbiological_process
GO:0032967Positive regulation of collagen biosynthetic processIEAbiological_process
GO:0033343Positive regulation of collagen bindingIEAbiological_process
GO:0033591Response to L-ascorbic acidIEAbiological_process
GO:0042060Wound healingIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043236Laminin bindingIEAmolecular_function
GO:0043388Positive regulation of DNA bindingIEAbiological_process
GO:0043589Skin morphogenesisIEAbiological_process
GO:0043679Axon terminusIEAcellular_component
GO:0045178Basal part of cellIEAcellular_component
GO:0045184Establishment of protein localizationIEAbiological_process
GO:0045727Positive regulation of translationIEAbiological_process
GO:0045785Positive regulation of cell adhesionIEAbiological_process
GO:0045987Positive regulation of smooth muscle contractionIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0048661Positive regulation of smooth muscle cell proliferationIEAbiological_process
GO:0050729Positive regulation of inflammatory responseIEAbiological_process
GO:0050927Positive regulation of positive chemotaxisIEAbiological_process
GO:0050966Detection of mechanical stimulus involved in sensory perception of painIEAbiological_process
GO:0051971Positive regulation of transmission of nerve impulseIEAbiological_process
GO:0060100Positive regulation of phagocytosis, engulfmentIEAbiological_process
GO:0070365Hepatocyte differentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00124124840.03868187380.09497354650.3706390972

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.7527599135
GSE13712_SHEARUp0.3585638110
GSE13712_STATICUp0.1485330392
GSE19018Down-0.9595146148
GSE19899_A1Up1.2912159120
GSE19899_A2Up0.2548086261
PubMed_21979375_A1Up0.2773807166
PubMed_21979375_A2Up0.6604229031
GSE35957Up1.2089949427
GSE36640Up1.5644328924
GSE54402Up0.6270328539
GSE9593Up0.3289919494
GSE43922Up0.6092106276
GSE24585Down-0.3966794434
GSE37065Up2.2207507846
GSE28863_A1Down-1.7323038739
GSE28863_A2Up1.0034605318
GSE28863_A3Down-2.2820412364
GSE28863_A4Down-0.2312562430
GSE48662Down-0.2016615206

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT001449pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-16-5pMIMAT0000069MIRT001449SequencingFunctional MTI (Weak)20371350
hsa-miR-30a-5pMIMAT0000087MIRT005123pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-335-5pMIMAT0000765MIRT017602MicroarrayFunctional MTI (Weak)18185580
hsa-miR-103a-3pMIMAT0000101MIRT027119SequencingFunctional MTI (Weak)20371350
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.