HCSGD entry for ITGA1
1. General information
| Official gene symbol | ITGA1 |
|---|---|
| Entrez ID | 3672 |
| Gene full name | integrin, alpha 1 |
| Other gene symbols | CD49a VLA1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000187 | Activation of MAPK activity | IEA | biological_process |
| GO:0001669 | Acrosomal vesicle | IEA | cellular_component |
| GO:0005178 | Integrin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005518 | Collagen binding | TAS | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006936 | Muscle contraction | TAS | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | IEA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IMP | biological_process |
| GO:0008305 | Integrin complex | TAS | cellular_component |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0019903 | Protein phosphatase binding | IPI | molecular_function |
| GO:0030593 | Neutrophil chemotaxis | IEA | biological_process |
| GO:0032516 | Positive regulation of phosphoprotein phosphatase activity | IDA | biological_process |
| GO:0042059 | Negative regulation of epidermal growth factor receptor signaling pathway | ISS | biological_process |
| GO:0042311 | Vasodilation | IEA | biological_process |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0043204 | Perikaryon | IEA | cellular_component |
| GO:0043525 | Positive regulation of neuron apoptotic process | IEA | biological_process |
| GO:0045121 | Membrane raft | IEA | cellular_component |
| GO:0045123 | Cellular extravasation | IEA | biological_process |
| GO:0045178 | Basal part of cell | IEA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9218914175 | 0.0203057939 | 0.9999902473 | 0.2761191632 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0157117949 |
| GSE13712_SHEAR | Up | 0.2109463327 |
| GSE13712_STATIC | Up | 0.1803226195 |
| GSE19018 | Down | -0.6401106534 |
| GSE19899_A1 | Down | -0.9554881752 |
| GSE19899_A2 | Down | -1.2981551349 |
| PubMed_21979375_A1 | Down | -0.9598492830 |
| PubMed_21979375_A2 | Down | -1.5838859749 |
| GSE35957 | Down | -0.4802359916 |
| GSE36640 | Up | 0.9557397222 |
| GSE54402 | Down | -0.2228575456 |
| GSE9593 | Down | -0.4796749042 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0270317901 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018439 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-1 | MIMAT0000416 | MIRT023883 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20225285 | The expressions of CD166, CD49a, and CD106 decreased, whereas those of CD10, CD29, CD44, CD73, CD90, and CD105 showed no significant change |
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