HCSGD entry for ISL1

1. General information

Official gene symbolISL1
Entrez ID3670
Gene full nameISL LIM homeobox 1
Other gene symbolsISLET1 Isl-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0001102RNA polymerase II activating transcription factor bindingIPImolecular_function
GO:0001105RNA polymerase II transcription coactivator activityIDAmolecular_function
GO:0001158Enhancer sequence-specific DNA bindingIDA NASmolecular_function
GO:0001755Neural crest cell migrationIEAbiological_process
GO:0003139Secondary heart field specificationIMPbiological_process
GO:0003148Outflow tract septum morphogenesisISSbiological_process
GO:0003151Outflow tract morphogenesisISSbiological_process
GO:0003203Endocardial cushion morphogenesisISSbiological_process
GO:0003215Cardiac right ventricle morphogenesisISSbiological_process
GO:0003266Regulation of secondary heart field cardioblast proliferationIEAbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIEA NAScellular_component
GO:0005737CytoplasmNAScellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0010575Positive regulation vascular endothelial growth factor productionISSbiological_process
GO:0016922Ligand-dependent nuclear receptor bindingISSmolecular_function
GO:0021520Spinal cord motor neuron cell fate specificationIEAbiological_process
GO:0021522Spinal cord motor neuron differentiationISSbiological_process
GO:0021524Visceral motor neuron differentiationIEAbiological_process
GO:0021559Trigeminal nerve developmentISSbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0030331Estrogen receptor bindingISSmolecular_function
GO:0031016Pancreas developmentISSbiological_process
GO:0031103Axon regenerationIEAbiological_process
GO:0031290Retinal ganglion cell axon guidanceIEAbiological_process
GO:0032024Positive regulation of insulin secretionICbiological_process
GO:0032725Positive regulation of granulocyte macrophage colony-stimulating factor productionISSbiological_process
GO:0032729Positive regulation of interferon-gamma productionISSbiological_process
GO:0032730Positive regulation of interleukin-1 alpha productionISSbiological_process
GO:0032731Positive regulation of interleukin-1 beta productionISSbiological_process
GO:0032735Positive regulation of interleukin-12 productionISSbiological_process
GO:0032755Positive regulation of interleukin-6 productionISSbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionISSbiological_process
GO:0033147Negative regulation of intracellular estrogen receptor signaling pathwayISSbiological_process
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinIEAbiological_process
GO:0043388Positive regulation of DNA bindingIEAbiological_process
GO:0043425BHLH transcription factor bindingIPImolecular_function
GO:0043524Negative regulation of neuron apoptotic processISSbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0045766Positive regulation of angiogenesisISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0048665Neuron fate specificationISSbiological_process
GO:0048762Mesenchymal cell differentiationISSbiological_process
GO:0048880Sensory system developmentISSbiological_process
GO:0048936Peripheral nervous system neuron axonogenesisISSbiological_process
GO:0050728Negative regulation of inflammatory responseISSbiological_process
GO:0055010Ventricular cardiac muscle tissue morphogenesisISSbiological_process
GO:0060037Pharyngeal system developmentISSbiological_process
GO:0060379Cardiac muscle cell myoblast differentiationIEAbiological_process
GO:0060384InnervationISSbiological_process
GO:0060413Atrial septum morphogenesisISSbiological_process
GO:0060913Cardiac cell fate determinationIDAbiological_process
GO:0071385Cellular response to glucocorticoid stimulusISSbiological_process
GO:0071657Positive regulation of granulocyte colony-stimulating factor productionISSbiological_process
GO:0090074Negative regulation of protein homodimerization activityISSbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIEAbiological_process
GO:1901258Positive regulation of macrophage colony-stimulating factor productionISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.26464195510.70831561870.95932253131.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0035353739
GSE13712_SHEARUp0.3688552895
GSE13712_STATICUp0.8728025622
GSE19018Up0.0483070221
GSE19899_A1Up0.1446748694
GSE19899_A2Up0.0672754005
PubMed_21979375_A1Up0.4109454465
PubMed_21979375_A2Up0.2236539109
GSE35957Up0.0856773711
GSE36640Down-0.0890729431
GSE54402Up0.0583161952
GSE9593Down-0.3636534459
GSE43922Up0.1059450113
GSE24585Down-0.5651192170
GSE37065Down-0.0252402460
GSE28863_A1Down-0.0959353436
GSE28863_A2Up0.1486325799
GSE28863_A3Up0.0548066777
GSE28863_A4Down-0.0422969540
GSE48662Up0.0658432240

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7d-5pMIMAT0000065MIRT032141SequencingFunctional MTI (Weak)20371350
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

206288278-fold and Isl1 60
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