HCSGD entry for ISG20

1. General information

Official gene symbolISG20
Entrez ID3669
Gene full nameinterferon stimulated exonuclease gene 20kDa
Other gene symbolsCD25 HEM45
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00001753'-5'-exoribonuclease activityIDAmolecular_function
GO:0000738DNA catabolic process, exonucleolyticIDAbiological_process
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0004527Exonuclease activityIEA IMPmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006364RRNA processingIEAbiological_process
GO:0006401RNA catabolic processIDAbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0008310Single-stranded DNA 3'-5' exodeoxyribonuclease activityIDAmolecular_function
GO:0008859Exoribonuclease II activityIEAmolecular_function
GO:0009615Response to virusIDAbiological_process
GO:0015030Cajal bodyIDAcellular_component
GO:0016605PML bodyIDAcellular_component
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0030619U1 snRNA bindingIDAmolecular_function
GO:0030620U2 snRNA bindingIDAmolecular_function
GO:0034511U3 snoRNA bindingIDAmolecular_function
GO:0045071Negative regulation of viral genome replicationIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051607Defense response to virusIMPbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0090501RNA phosphodiester bond hydrolysisIDAbiological_process
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolyticIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02377864060.31229625010.36601029241.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1136719963
GSE13712_SHEARUp1.0951372710
GSE13712_STATICUp2.8666461918
GSE19018Down-0.0896860115
GSE19899_A1Up0.2936264571
GSE19899_A2Down-0.0846894925
PubMed_21979375_A1Up0.3254307925
PubMed_21979375_A2Up0.1927218028
GSE35957Down-1.9876674488
GSE36640Down-1.0049465336
GSE54402Up0.9820064926
GSE9593Down-0.1892656489
GSE43922Up0.0440723842
GSE24585Down-0.1322105155
GSE37065Up0.7876485467
GSE28863_A1Down-0.1343255064
GSE28863_A2Down-0.2878281410
GSE28863_A3Up0.1540074818
GSE28863_A4Up0.1065654604
GSE48662Up0.4099558287

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Uridine-5'-MonophosphateDB03685 EXPT03155

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018907MicroarrayFunctional MTI (Weak)18185580
hsa-miR-1MIMAT0000416MIRT024004MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.