HCSGD entry for IRF7

1. General information

Official gene symbolIRF7
Entrez ID3665
Gene full nameinterferon regulatory factor 7
Other gene symbolsIRF-7H IRF7A IRF7B IRF7C IRF7H
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0000975Regulatory region DNA bindingIEAmolecular_function
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIDAmolecular_function
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0002819Regulation of adaptive immune responseIDAbiological_process
GO:0003677DNA bindingIMPmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusTAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006974Cellular response to DNA damage stimulusTASbiological_process
GO:0009615Response to virusTASbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0016064Immunoglobulin mediated immune responseIEAbiological_process
GO:0019043Establishment of viral latencyTASbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0032479Regulation of type I interferon productionTASbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0032607Interferon-alpha productionIEA ISSbiological_process
GO:0032608Interferon-beta productionIEA ISSbiological_process
GO:0032727Positive regulation of interferon-alpha productionIDA TASbiological_process
GO:0032728Positive regulation of interferon-beta productionTASbiological_process
GO:0034124Regulation of MyD88-dependent toll-like receptor signaling pathwayIEA ISSbiological_process
GO:0034127Regulation of MyD88-independent toll-like receptor signaling pathwayIEA ISSbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0039530MDA-5 signaling pathwayTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045351Type I interferon biosynthetic processIEAbiological_process
GO:0045655Regulation of monocyte differentiationTASbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0050776Regulation of immune responseTASbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0060340Positive regulation of type I interferon-mediated signaling pathwayIEAbiological_process
GO:2000110Negative regulation of macrophage apoptotic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01245999770.80699834350.27910857391.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5681176241
GSE13712_SHEARUp2.8997360601
GSE13712_STATICUp1.0655167735
GSE19018Up0.2020617815
GSE19899_A1Down-0.1404981977
GSE19899_A2Down-0.0783933269
PubMed_21979375_A1Up0.3060325923
PubMed_21979375_A2Down-0.1432650818
GSE35957Down-2.5765971483
GSE36640Up0.1686169272
GSE54402Up0.1447361219
GSE9593Down-0.1784207924
GSE43922Up0.1055650044
GSE24585Up0.8523345600
GSE37065Up0.4654638330
GSE28863_A1Down-0.0667640062
GSE28863_A2Up0.4404234144
GSE28863_A3Up0.3406000656
GSE28863_A4Up0.0846781821
GSE48662Up0.2685309623

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-146a-5pMIMAT0000449MIRT021215MicroarrayFunctional MTI (Weak)18057241
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19802007Here, we show that genotoxic drugs capable of inducing premature senescence in normal and cancer cells, such as 5-bromo-2'-deoxyuridine (BrdU), distamycin A (DMA), aphidicolin and hydroxyurea, persistently activate Janus kinase-signal transducer and activator of transcription (JAK/STAT) signaling and expression of interferon-stimulated genes (ISGs), such as MX1, OAS, ISG15, STAT1, PML, IRF1 and IRF7, in several human cancer cell lines
18505922Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts
18505922Bisulfite sequencing of the promoter regions of two IFN regulatory transcription factors (IRF5 and IRF7) revealed that IRF7, but not IRF5, was epigenetically silenced by methylation of CpG islands in immortal LFS cells
18505922We conclude that the epigenetic inactivation of the IFN pathway plays a critical role in cellular immortalization, and the reactivation of IFN-regulated genes by transcription factors IRF5 and/or IRF7 is sufficient to induce cellular senescence
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