HCSGD entry for IRF6
1. General information
| Official gene symbol | IRF6 |
|---|---|
| Entrez ID | 3664 |
| Gene full name | interferon regulatory factor 6 |
| Other gene symbols | LPS OFC6 PIT PPS PPS1 VWS VWS1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000975 | Regulatory region DNA binding | IEA | molecular_function |
| GO:0003677 | DNA binding | ISS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | IDA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IDA IEA | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0030216 | Keratinocyte differentiation | IEA | biological_process |
| GO:0043616 | Keratinocyte proliferation | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA ISS | biological_process |
| GO:0048468 | Cell development | IEA | biological_process |
| GO:0060333 | Interferon-gamma-mediated signaling pathway | TAS | biological_process |
| GO:0060337 | Type I interferon signaling pathway | TAS | biological_process |
| GO:0060644 | Mammary gland epithelial cell differentiation | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9377554880 | 0.0063161468 | 0.9999902473 | 0.1617048591 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0427781802 |
| GSE13712_SHEAR | Down | -3.1602543051 |
| GSE13712_STATIC | Down | -3.1469726361 |
| GSE19018 | Up | 0.0771513813 |
| GSE19899_A1 | Up | 0.0859654938 |
| GSE19899_A2 | Down | -0.1519980112 |
| PubMed_21979375_A1 | Down | -0.6350855367 |
| PubMed_21979375_A2 | Down | -0.3373001128 |
| GSE35957 | Up | 0.2342013343 |
| GSE36640 | Down | -0.4466154801 |
| GSE54402 | Down | -0.5183976850 |
| GSE9593 | Down | -0.0307060644 |
| GSE43922 | Down | -0.2143076596 |
| GSE24585 | Up | 0.8984970487 |
| GSE37065 | Up | 0.2753677151 |
| GSE28863_A1 | Down | -0.4982954496 |
| GSE28863_A2 | Up | 0.0063286869 |
| GSE28863_A3 | Down | -0.6584179666 |
| GSE28863_A4 | Down | -0.0848273853 |
| GSE48662 | Down | -0.0611724135 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018970 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
