HCSGD entry for IRF4

1. General information

Official gene symbolIRF4
Entrez ID3662
Gene full nameinterferon regulatory factor 4
Other gene symbolsLSIRF MUM1 NF-EM5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000788Nuclear nucleosomeIEAcellular_component
GO:0000975Regulatory region DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEA ISS NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIC IDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0008134Transcription factor bindingNASmolecular_function
GO:0016279Protein-lysine N-methyltransferase activityIEAmolecular_function
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0034122Negative regulation of toll-like receptor signaling pathwayIEAbiological_process
GO:0042110T cell activationNASbiological_process
GO:0042832Defense response to protozoanISSbiological_process
GO:0043011Myeloid dendritic cell differentiationIEAbiological_process
GO:0043388Positive regulation of DNA bindingIEAbiological_process
GO:0043565Sequence-specific DNA bindingISSmolecular_function
GO:0043966Histone H3 acetylationIEAbiological_process
GO:0043967Histone H4 acetylationIEAbiological_process
GO:0045082Positive regulation of interleukin-10 biosynthetic processIDAbiological_process
GO:0045086Positive regulation of interleukin-2 biosynthetic processIDAbiological_process
GO:0045368Positive regulation of interleukin-13 biosynthetic processIDAbiological_process
GO:0045404Positive regulation of interleukin-4 biosynthetic processIDAbiological_process
GO:0045622Regulation of T-helper cell differentiationNASbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0072540T-helper 17 cell lineage commitmentISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.44797554040.32812113900.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0275603857
GSE13712_SHEARUp0.0186381103
GSE13712_STATICUp0.0597965560
GSE19018Up0.1556558278
GSE19899_A1Up0.0490643266
GSE19899_A2Down-0.0935216210
PubMed_21979375_A1Down-0.0104909603
PubMed_21979375_A2Up0.0913085798
GSE35957Up0.1619131414
GSE36640Down-0.0051117711
GSE54402Up0.0459177773
GSE9593Up0.0358906195
GSE43922Up0.0339317736
GSE24585Up1.3860019314
GSE37065Down-0.0445223457
GSE28863_A1Down-0.8460024400
GSE28863_A2Down-0.7651740532
GSE28863_A3Up0.0764720285
GSE28863_A4Down-0.0261725333
GSE48662Up0.0224391407

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125b-5pMIMAT0000423MIRT004534qRT-PCR//Luciferase reporter assayFunctional MTI20497960
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25540416EBNA3A was at MYC, CDKN2A/B, CCND2, CXCL9/10, and BCL2, together with RUNX3, BATF, IRF4, and SPI1
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