HCSGD entry for IRF1

1. General information

Official gene symbolIRF1
Entrez ID3659
Gene full nameinterferon regulatory factor 1
Other gene symbolsIRF-1 MAR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000790Nuclear chromatinIDAcellular_component
GO:0000975Regulatory region DNA bindingIEAmolecular_function
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0002819Regulation of adaptive immune responseTASbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusTAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEA ISScellular_component
GO:0005829CytosolTAScellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006915Apoptotic processIDAbiological_process
GO:0007050Cell cycle arrestIDAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008285Negative regulation of cell proliferationTASbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0032481Positive regulation of type I interferon productionIEA ISSbiological_process
GO:0032728Positive regulation of interferon-beta productionIMPbiological_process
GO:0034124Regulation of MyD88-dependent toll-like receptor signaling pathwayIEA ISSbiological_process
GO:0035458Cellular response to interferon-betaIDAbiological_process
GO:0043374CD8-positive, alpha-beta T cell differentiationIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045084Positive regulation of interleukin-12 biosynthetic processIEAbiological_process
GO:0045088Regulation of innate immune responseTASbiological_process
GO:0045590Negative regulation of regulatory T cell differentiationIEA ISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0051607Defense response to virusIDAbiological_process
GO:0051726Regulation of cell cycleTASbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayIEA ISS TASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
GO:2000564Regulation of CD8-positive, alpha-beta T cell proliferationIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00150406140.97518300600.10458950131.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6949501625
GSE13712_SHEARUp0.2542781913
GSE13712_STATICUp0.5370380038
GSE19018Down-0.1677755467
GSE19899_A1Up0.3821736182
GSE19899_A2Up1.0898679906
PubMed_21979375_A1Up1.1808428412
PubMed_21979375_A2Up2.3672816993
GSE35957Down-0.1403883995
GSE36640Up2.1097967996
GSE54402Up0.3639957741
GSE9593Up0.6333874472
GSE43922Up0.1420600775
GSE24585Up0.3061232842
GSE37065Up0.5692663630
GSE28863_A1Up0.1763793664
GSE28863_A2Up0.5406100556
GSE28863_A3Down-0.3044561030
GSE28863_A4Down-0.1671535086
GSE48662Up0.0610046921

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-383-5pMIMAT0000738MIRT006535Flow//Immunofluorescence//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21368870
hsa-miR-93-5pMIMAT0000093MIRT027994SequencingFunctional MTI (Weak)20371350
hsa-miR-296-3pMIMAT0004679MIRT038441CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21197417Interferon Regulatory Factor-1 (IRF-1) plays an important role in the transcriptional regulation of the IFN response, cell cycle and apoptosis
21197417We have studied pIFN-alpha induced responses when combined with the chemotherapy agent, vinblastine in tumor and endothelial cell lines and the connection to IRF-1 signaling
21197417Levels of IRF-1/IRF-2 protein expression were found to be decreased in tumor versus normal tissues
19802007Here, we show that genotoxic drugs capable of inducing premature senescence in normal and cancer cells, such as 5-bromo-2'-deoxyuridine (BrdU), distamycin A (DMA), aphidicolin and hydroxyurea, persistently activate Janus kinase-signal transducer and activator of transcription (JAK/STAT) signaling and expression of interferon-stimulated genes (ISGs), such as MX1, OAS, ISG15, STAT1, PML, IRF1 and IRF7, in several human cancer cell lines
10049783Furthermore, the expression of mRNAs for p21/Waf1/Cip1/Sdi1, IRF-1 and IFN inducible 6-16 was higher in the telomere-reduced cells than in the parental cells
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