HCSGD entry for IRAK2

1. General information

Official gene symbolIRAK2
Entrez ID3656
Gene full nameinterleukin-1 receptor-associated kinase 2
Other gene symbolsIRAK-2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0001959Regulation of cytokine-mediated signaling pathwayIMPbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0007249I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0031663Lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityIMPbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0051092Positive regulation of NF-kappaB transcription factor activityIMP TASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
GO:0070498Interleukin-1-mediated signaling pathwayIMPbiological_process
GO:0070555Response to interleukin-1IMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00156147940.99404071270.10606185571.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2793606251
GSE13712_SHEARUp0.4160372009
GSE13712_STATICUp0.3400347736
GSE19018Down-0.1058332215
GSE19899_A1Up0.5929328109
GSE19899_A2Up1.2683517295
PubMed_21979375_A1Up1.2047861011
PubMed_21979375_A2Up1.1935346746
GSE35957Down-0.0849123734
GSE36640Up0.2366476616
GSE54402Up0.6754464001
GSE9593Up0.2922039122
GSE43922Up1.7837192056
GSE24585Up0.0151506983
GSE37065Up1.5015725961
GSE28863_A1Up0.1078269906
GSE28863_A2Up0.4555039719
GSE28863_A3Up0.2512515257
GSE28863_A4Up0.1439180953
GSE48662Down-0.4088984463

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-146a-5pMIMAT0000449MIRT000304qRT-PCR//Western blotFunctional MTI20124483
hsa-miR-335-5pMIMAT0000765MIRT017238MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.