HCSGD entry for ITGA6
1. General information
| Official gene symbol | ITGA6 |
|---|---|
| Entrez ID | 3655 |
| Gene full name | integrin, alpha 6 |
| Other gene symbols | CD49f ITGA6B VLA-6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005178 | Integrin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005604 | Basement membrane | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005913 | Cell-cell adherens junction | IEA | cellular_component |
| GO:0007044 | Cell-substrate junction assembly | TAS | biological_process |
| GO:0007160 | Cell-matrix adhesion | IEA | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0009925 | Basal plasma membrane | IEA | cellular_component |
| GO:0010811 | Positive regulation of cell-substrate adhesion | IEA | biological_process |
| GO:0016337 | Cell-cell adhesion | IEA | biological_process |
| GO:0022409 | Positive regulation of cell-cell adhesion | IEA | biological_process |
| GO:0030056 | Hemidesmosome | IEA | cellular_component |
| GO:0030175 | Filopodium | IEA | cellular_component |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0031581 | Hemidesmosome assembly | TAS | biological_process |
| GO:0031668 | Cellular response to extracellular stimulus | IEA | biological_process |
| GO:0033627 | Cell adhesion mediated by integrin | IEA | biological_process |
| GO:0034329 | Cell junction assembly | TAS | biological_process |
| GO:0034676 | Alpha6-beta4 integrin complex | IEA | cellular_component |
| GO:0042327 | Positive regulation of phosphorylation | IMP | biological_process |
| GO:0042475 | Odontogenesis of dentin-containing tooth | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IGI | biological_process |
| GO:0043236 | Laminin binding | IEA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0046847 | Filopodium assembly | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050873 | Brown fat cell differentiation | IEA | biological_process |
| GO:0050900 | Leukocyte migration | IEA TAS | biological_process |
| GO:0071407 | Cellular response to organic cyclic compound | IEA | biological_process |
| GO:2001237 | Negative regulation of extrinsic apoptotic signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1411882413 | 0.0127645682 | 0.7545815431 | 0.2230917663 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2546928410 |
| GSE13712_SHEAR | Up | 0.0278327586 |
| GSE13712_STATIC | Down | -0.1365042421 |
| GSE19018 | Up | 0.8538630668 |
| GSE19899_A1 | Down | -0.0562081877 |
| GSE19899_A2 | Down | -0.5561004133 |
| PubMed_21979375_A1 | Down | -1.9359036810 |
| PubMed_21979375_A2 | Down | -1.2589976321 |
| GSE35957 | Up | 0.6228688972 |
| GSE36640 | Down | -0.1046702971 |
| GSE54402 | Down | -0.4770279840 |
| GSE9593 | Up | 0.0328822147 |
| GSE43922 | Down | -0.6530967131 |
| GSE24585 | Up | 1.2339507565 |
| GSE37065 | Up | 0.5373036610 |
| GSE28863_A1 | Down | -0.9365552127 |
| GSE28863_A2 | Down | -0.4136086738 |
| GSE28863_A3 | Down | -0.5737297855 |
| GSE28863_A4 | Up | 0.1328843895 |
| GSE48662 | Down | -0.2006801822 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023546 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT023546 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025291 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028271 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028474 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046458 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
