HCSGD entry for EIF3E
1. General information
| Official gene symbol | EIF3E |
|---|---|
| Entrez ID | 3646 |
| Gene full name | eukaryotic translation initiation factor 3, subunit E |
| Other gene symbols | EIF3-P48 EIF3S6 INT6 eIF3-p46 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000184 | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | IMP | biological_process |
| GO:0000785 | Chromatin | NAS | cellular_component |
| GO:0001731 | Formation of translation preinitiation complex | IEA | biological_process |
| GO:0003743 | Translation initiation factor activity | IC IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | NAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005852 | Eukaryotic translation initiation factor 3 complex | IDA IEA NAS | cellular_component |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006413 | Translational initiation | IC IDA TAS | biological_process |
| GO:0006446 | Regulation of translational initiation | IEA NAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016282 | Eukaryotic 43S preinitiation complex | IEA | cellular_component |
| GO:0016605 | PML body | IDA IEA | cellular_component |
| GO:0033290 | Eukaryotic 48S preinitiation complex | IEA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045947 | Negative regulation of translational initiation | NAS | biological_process |
| GO:0047485 | Protein N-terminus binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9382213708 | 0.0701382584 | 0.9999902473 | 0.5001650230 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1290740185 |
| GSE13712_SHEAR | Up | 0.0109158801 |
| GSE13712_STATIC | Up | 0.5443878153 |
| GSE19018 | Up | 0.1282367159 |
| GSE19899_A1 | Down | -0.0564615226 |
| GSE19899_A2 | Down | -0.2713233217 |
| PubMed_21979375_A1 | Down | -0.7908901271 |
| PubMed_21979375_A2 | Down | -0.1756838139 |
| GSE35957 | Down | -0.0175367474 |
| GSE36640 | Down | -0.4907550601 |
| GSE54402 | Down | -0.1399855291 |
| GSE9593 | Down | -0.2150992756 |
| GSE43922 | Up | 0.0385857507 |
| GSE24585 | Down | -0.3216447476 |
| GSE37065 | Down | -0.2380071237 |
| GSE28863_A1 | Up | 0.1165230134 |
| GSE28863_A2 | Down | -0.1936095754 |
| GSE28863_A3 | Down | -0.1113969443 |
| GSE28863_A4 | Down | -0.0084742508 |
| GSE48662 | Down | -0.3345426656 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020499 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031475 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-29a-3p | MIMAT0000086 | MIRT049969 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
