HCSGD entry for INSIG1
1. General information
| Official gene symbol | INSIG1 |
|---|---|
| Entrez ID | 3638 |
| Gene full name | insulin induced gene 1 |
| Other gene symbols | CL-6 CL6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006641 | Triglyceride metabolic process | IEA | biological_process |
| GO:0006695 | Cholesterol biosynthetic process | IEA | biological_process |
| GO:0006991 | Response to sterol depletion | IEA | biological_process |
| GO:0008152 | Metabolic process | TAS | biological_process |
| GO:0008203 | Cholesterol metabolic process | IEA | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0010894 | Negative regulation of steroid biosynthetic process | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0032933 | SREBP signaling pathway | IDA | biological_process |
| GO:0032937 | SREBP-SCAP-Insig complex | IDA | cellular_component |
| GO:0042472 | Inner ear morphogenesis | IEA | biological_process |
| GO:0042474 | Middle ear morphogenesis | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045599 | Negative regulation of fat cell differentiation | IEA | biological_process |
| GO:0045717 | Negative regulation of fatty acid biosynthetic process | IEA | biological_process |
| GO:0060021 | Palate development | IEA | biological_process |
| GO:0060363 | Cranial suture morphogenesis | IEA | biological_process |
| GO:1901303 | Negative regulation of cargo loading into COPII-coated vesicle | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0425327533 | 0.0257881387 | 0.4605119704 | 0.3083268392 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5125536940 |
| GSE13712_SHEAR | Down | -0.7676309037 |
| GSE13712_STATIC | Down | -0.5762071913 |
| GSE19018 | Down | -0.4456970921 |
| GSE19899_A1 | Up | 1.3312339910 |
| GSE19899_A2 | Up | 1.3997605952 |
| PubMed_21979375_A1 | Down | -0.1069911627 |
| PubMed_21979375_A2 | Up | 1.0006854010 |
| GSE35957 | Down | -0.7377612871 |
| GSE36640 | Down | -0.5725867486 |
| GSE54402 | Up | 1.4364913666 |
| GSE9593 | Down | -0.1183299059 |
| GSE43922 | Up | 0.1581055286 |
| GSE24585 | Down | -0.9480386419 |
| GSE37065 | Up | 0.0069819335 |
| GSE28863_A1 | Up | 0.0506774047 |
| GSE28863_A2 | Up | 0.5560932645 |
| GSE28863_A3 | Down | -0.0186914130 |
| GSE28863_A4 | Down | -0.3075092528 |
| GSE48662 | Down | -1.2866848181 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018237 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024948 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026622 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-107 | MIMAT0000104 | MIRT026975 | Microarray | Functional MTI (Weak) | 20489155 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027042 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028320 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041286 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044329 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047148 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048485 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT048978 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050481 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23500545 | The mechanisms by which oxysterols may influence proliferation are manifold: they control the transcription and the turnover of the key enzyme in cholesterol synthesis, 3-hydroxy-3-methylglutaryl CoA reductase, by binding to Insig-1, Insig-2 and liver X receptors |
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