HCSGD entry for CXCL10

1. General information

Official gene symbolCXCL10
Entrez ID3627
Gene full namechemokine (C-X-C motif) ligand 10
Other gene symbolsC7 IFI10 INP10 IP-10 SCYB10 crg-2 gIP-10 mob-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002690Positive regulation of leukocyte chemotaxisIEAbiological_process
GO:0005102Receptor bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIDA TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006935ChemotaxisIDAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIMPbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007517Muscle organ developmentTASbiological_process
GO:0008009Chemokine activityIDAmolecular_function
GO:0008015Blood circulationTASbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008603CAMP-dependent protein kinase regulator activityTASmolecular_function
GO:0009306Protein secretionIEAbiological_process
GO:0009409Response to coldIEAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0010332Response to gamma radiationIEAbiological_process
GO:0010996Response to auditory stimulusIEAbiological_process
GO:0016525Negative regulation of angiogenesisIEAbiological_process
GO:0030816Positive regulation of cAMP metabolic processIDAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0033280Response to vitamin DIEAbiological_process
GO:0034605Cellular response to heatIEAbiological_process
GO:0042127Regulation of cell proliferationIDAbiological_process
GO:0042325Regulation of phosphorylationTASbiological_process
GO:0043950Positive regulation of cAMP-mediated signalingIDAbiological_process
GO:0045859Regulation of protein kinase activityTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0048248CXCR3 chemokine receptor bindingIDAmolecular_function
GO:0050790Regulation of catalytic activityTASbiological_process
GO:0051281Positive regulation of release of sequestered calcium ion into cytosolIDAbiological_process
GO:0051607Defense response to virusIEAbiological_process
GO:0060326Cell chemotaxisIDA TASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00009594620.94415282470.02777526881.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1029886839
GSE13712_SHEARUp1.6925783048
GSE13712_STATICUp2.6422772157
GSE19018Down-0.4554981763
GSE19899_A1Up1.3662950880
GSE19899_A2Up4.1036228061
PubMed_21979375_A1Up1.2954190016
PubMed_21979375_A2Up3.9903791382
GSE35957Down-1.0267062199
GSE36640Up3.4996392270
GSE54402Up0.0715397978
GSE9593Up0.1761924904
GSE43922Up4.0235132349
GSE24585Up0.0172061628
GSE37065Up2.7954164144
GSE28863_A1Up0.0196051219
GSE28863_A2Up0.1508623616
GSE28863_A3Up0.0852074606
GSE28863_A4Up0.0623749582
GSE48662Down-0.0152040914

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

N-MethylleucineDB04487 EXPT02181

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24499954Changes were related to proportions of CD4 T cells expressing HLA-DR or CD57 and plasma levels of sCD14, CXCL9 and CXCL10
18716376Angiotensin II increases expression of IP-10 and the renin-angiotensin system in endothelial cells
18716376In this study, we found that angiotensin II-stimulated human endothelial cells increased the release of a CXC chemokine, IP-10, according to an antibody array
18716376IP-10 expression was higher in the endothelium of coronary blood vessels in mice infused with angiotensin II than in control
18716376Quantitative real-time PCR analysis revealed that angiotensin II significantly increased IP-10 mRNA expression compared to control
18716376Pretreatment with valsartan, but not with PD123319, blocked angiotensin II-induced IP-10 mRNA expression
18716376IP-10 levels in conditioned media detected by ELISA increased in response to angiotensin II compared to control, which was blocked by the pretreatment with valsartan
18716376These data indicate that angiotensin II stimulates IP-10 production from endothelial cells via angiotensin II type 1 receptors
18716376In endothelial cells, IP-10 significantly increased mRNA expression of renin, angiotensin-converting enzyme, and angiotensinogen
18716376IP-10 also increased angiotensin II levels in conditioned media compared to control
18716376Angiotensin II significantly increased mRNA expression of renin, angiotensin converting enzyme and angiotensinogen, which was blocked by neutralization of IP-10 with antibody in endothelial cells
18716376IP-10 neutralization with antibody blocked angiotensin II-induced apoptosis and cell senescence in endothelial cells
18716376These data indicate that IP-10 is involved not only in leukocyte-endothelial interaction but also in the circuit of endothelial renin-angiotensin system activation that potentially promotes atherosclerosis
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