HCSGD entry for ING2
1. General information
| Official gene symbol | ING2 |
|---|---|
| Entrez ID | 3622 |
| Gene full name | inhibitor of growth family, member 2 |
| Other gene symbols | ING1L p33ING2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003682 | Chromatin binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0007141 | Male meiosis I | ISS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007283 | Spermatogenesis | ISS | biological_process |
| GO:0007286 | Spermatid development | ISS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016568 | Chromatin modification | ISS | biological_process |
| GO:0016580 | Sin3 complex | IDA | cellular_component |
| GO:0016602 | CCAAT-binding factor complex | IDA | cellular_component |
| GO:0030317 | Sperm motility | ISS | biological_process |
| GO:0030511 | Positive regulation of transforming growth factor beta receptor signaling pathway | IDA | biological_process |
| GO:0032403 | Protein complex binding | IDA | molecular_function |
| GO:0035064 | Methylated histone residue binding | IDA | molecular_function |
| GO:0035091 | Phosphatidylinositol binding | IDA | molecular_function |
| GO:0040008 | Regulation of growth | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0048133 | Male germ-line stem cell division | ISS | biological_process |
| GO:0072520 | Seminiferous tubule development | ISS | biological_process |
| GO:1902166 | Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | TAS | biological_process |
| GO:2000772 | Regulation of cellular senescence | NAS | biological_process |
| GO:2001020 | Regulation of response to DNA damage stimulus | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6755766878 | 0.2548001292 | 0.9999902473 | 0.9680418880 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2072985684 |
| GSE13712_SHEAR | Down | -0.2436203894 |
| GSE13712_STATIC | Down | -0.1543677136 |
| GSE19018 | Up | 0.1362336086 |
| GSE19899_A1 | Up | 0.0462554153 |
| GSE19899_A2 | Down | -0.0213578435 |
| PubMed_21979375_A1 | Up | 0.9693676101 |
| PubMed_21979375_A2 | Down | -0.3257957075 |
| GSE35957 | Down | -0.5732698749 |
| GSE36640 | Down | -0.9394430946 |
| GSE54402 | Up | 0.2443619347 |
| GSE9593 | Down | -0.0141371194 |
| GSE43922 | Up | 0.0531075379 |
| GSE24585 | Up | 0.0201078711 |
| GSE37065 | Up | 0.1266168038 |
| GSE28863_A1 | Up | 0.0376537629 |
| GSE28863_A2 | Up | 0.0709590131 |
| GSE28863_A3 | Down | -0.1800932769 |
| GSE28863_A4 | Down | -0.1303578342 |
| GSE48662 | Down | -0.4932117550 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029061 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27305909 | A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling |
| 27305909 | Inhibitor of growth 1 (ING1) and ING2 are tumor suppressors with reduced expression in many cancer types |
| 27305909 | There are also indications of misregulation of ING1 and ING2 in PCa |
| 27305909 | However, the roles of ING1 and ING2 in PCa and AR signaling are poorly understood |
| 27305909 | The unexpected finding that the ING1 KD results in growth inhibition was further analyzed and can be explained by a compensatory mechanism through enhanced levels of ING2 protein in ING1-deficient condition |
| 27305909 | Accordingly, the data suggest that ING2 interacts with AR and hampers the AR transcriptional activation, causes growth arrest, and induces cellular senescence |
| 27305909 | The data further suggest that ING2 upregulates p16 INK4a , which is a novel target for ING2 |
| 27305909 | The data further suggest that ING2 upregulates p16 INK4a , which is a novel target for ING2 |
| 27305909 | Taken together, our data suggest that ING2 is a novel corepressor for AR |
| 27305909 | ING2 levels are increased upon downregulation of ING1 expression indicating a compensatory mechanism and suggests a novel crosstalk between ING1 and ING2 tumor suppressors to inhibit AR signaling and induce cellular senescence in PCa cells |
| 27305909 | ING2 levels are increased upon downregulation of ING1 expression indicating a compensatory mechanism and suggests a novel crosstalk between ING1 and ING2 tumor suppressors to inhibit AR signaling and induce cellular senescence in PCa cells |
| 25672483 | ING2 (inhibitor of growth protein-2) plays a crucial role in preimplantation development |
| 25672483 | ING2 (inhibitor of growth protein-2) is a member of the ING-gene family and participates in diverse cellular processes involving tumor suppression, DNA repair, cell cycle regulation, and cellular senescence |
| 25672483 | As a subunit of the Sin3 histone deacetylase complex co-repressor complex, ING2 binds to H3K4me3 to regulate chromatin modification and gene expression |
| 25672483 | Additionally, ING2 recruits histone methyltransferase (HMT) activity for gene repression, which is independent of the HDAC class I or II pathway |
| 25672483 | However, the physiological function of ING2 in mouse preimplantation embryo development has not yet been characterized previously |
| 25672483 | The expression, localization and function of ING2 during preimplantation development were investigated in this study |
| 25672483 | We showed increasing expression of ING2 within the nucleus from the 4-cell embryo stage onwards; and that down-regulation of ING2 expression by endoribonuclease-prepared small interfering RNA (esiRNA) microinjection results in developmental arrest during the morula to blastocyst transition |
| 25672483 | We showed increasing expression of ING2 within the nucleus from the 4-cell embryo stage onwards; and that down-regulation of ING2 expression by endoribonuclease-prepared small interfering RNA (esiRNA) microinjection results in developmental arrest during the morula to blastocyst transition |
| 25672483 | Further investigation of the underlying mechanism indicated that down-regulation of ING2 significantly increased expression of p21, whilst decreasing expression of HDAC1 |
| 25672483 | These results suggest that ING2 may play a crucial role in the process of preimplantation embryo development through chromatin regulation |
| 21767350 | While ING1, ING2 and ING3 proteins are stable components of the mSIN3a-HDAC complexes, the association of ING1, ING4 and ING5 with HAT protein complexes was also reported |
| 21767350 | Among these the ING1 and ING2 have been analyzed more deeply |
| 21767350 | ING1 and ING2 are localized in the cell nucleus and associated with chromatin modifying enzymes, linking tumor suppression directly to chromatin regulation |
| 21767350 | Recent analyses of ING1- and ING2-deficient mice confirm a tumor suppressive role of ING1 and ING2 and also indicate an essential role of ING2 in meiosis |
| 21767350 | Recent analyses of ING1- and ING2-deficient mice confirm a tumor suppressive role of ING1 and ING2 and also indicate an essential role of ING2 in meiosis |
| 21767350 | Here we summarize the activity of ING1 and ING2 as tumor suppressors, chromatin factors and in development |
| 21124965 | ING2 (inhibitor of growth family, member 2) is a member of the plant homeodomain (PHD)-containing ING family of putative tumor suppressors |
| 21124965 | ING2 (inhibitor of growth family, member 2) is a member of the plant homeodomain (PHD)-containing ING family of putative tumor suppressors |
| 21124965 | As part of mSin3A-HDAC corepressor complexes, ING2 binds to tri-methylated lysine 4 of histone H3 (H3K4me3) to regulate chromatin modification and gene expression |
| 21124965 | ING2 also functionally interacts with the tumor suppressor protein p53 to regulate cellular senescence, apoptosis and DNA damage response in vitro, and is thus expected to modulate carcinogenesis and aging |
| 21124965 | Using publicly available gene expression datasets, low expression of ING2 was found in teratozoospermic sperm (>3-fold reduction) and in testes from patients with defective spermatogenesis (>7-fold reduction in Sertoli-cell only Syndrome) |
| 21124965 | This study establishes ING2 as a novel regulator of spermatogenesis functioning through both p53- and chromatin-mediated mechanisms, suggests that an HDAC1/ING2/H3K4me3-regulated, stage-specific coordination of chromatin modifications is essential to normal spermatogenesis, and provides an animal model to study idiopathic and iatrogenic infertility in men |
| 19442113 | Here, we review the evidence on the participation of ING proteins, mainly ING1 and ING2, in the implementation of the senescent response |
| 18513492 | ING2 recruits histone methyltransferase activity with methylation site specificity distinct from histone H3 lysines 4 and 9 |
| 18513492 | Here, we show that p33ING2 contains a transferable silencing function, which is independent of p53 |
| 18513492 | In line with that we show that p33ING2 is associated with histone methyltransferase (HMT) activity in vitro and in vivo, methylating specifically histone H3 |
| 18513492 | Mutation or methylation of lysine 9, a mark well known for repression, abrogates histone methylation by MeCP2 but not by the p33ING2 complex |
| 18513492 | Deletion analyses revealed that the ING2 C-terminus recruits HMT activity, which correlates with silencing function |
| 18451145 | Two candidates for a p53-DNA binding consensus sequence were found in the ING2 promoter regulatory region; thus, we performed chromatin immunoprecipitation and electrophoretic mobility shift assays and confirmed p53 binding directly to those sites |
| 18451145 | In addition, the luciferase activity of a construct containing the ING2 regulatory region was repressed after p53 activation |
| 18451145 | Antisense knockdown of ING2 induces p53-independent senescence, whereas overexpression of ING2 induces p53-dependent senescence |
| 18451145 | Antisense knockdown of ING2 induces p53-independent senescence, whereas overexpression of ING2 induces p53-dependent senescence |
| 18451145 | Taken together, we conclude that nutlin-3a induces senescence through p53 activation in normal human fibroblasts, and p53-mediated mir34a, mir34b, and mir34c up-regulation and ING2 down-regulation may be involved in the senescence pathway |
| 16520380 | Because ING1b and ING2 have been shown to be involved in cellular stress responses such as nucleotide excision repair and apoptosis after UV irradiation, we investigated whether ING3 also mediated UV-induced apoptosis |
| 16520380 | Unlike its homologues ING1b and ING2, ING3-increased apoptosis was independent of functional p53 |
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