HCSGD entry for IDO1

1. General information

Official gene symbolIDO1
Entrez ID3620
Gene full nameindoleamine 2,3-dioxygenase 1
Other gene symbolsIDO IDO-1 INDO
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002534Cytokine production involved in inflammatory responseIEAbiological_process
GO:0002666Positive regulation of T cell tolerance inductionIEAbiological_process
GO:0002678Positive regulation of chronic inflammatory responseIEAbiological_process
GO:0002830Positive regulation of type 2 immune responseIEAbiological_process
GO:0004833Tryptophan 2,3-dioxygenase activityEXP IEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006569Tryptophan catabolic processTASbiological_process
GO:0007565Female pregnancyTASbiological_process
GO:0009055Electron carrier activityTASmolecular_function
GO:0019441Tryptophan catabolic process to kynurenineIEAbiological_process
GO:0020037Heme bindingIEAmolecular_function
GO:0030485Smooth muscle contractile fiberIEAcellular_component
GO:0032421Stereocilium bundleIEAcellular_component
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0032693Negative regulation of interleukin-10 productionIEAbiological_process
GO:0032735Positive regulation of interleukin-12 productionIEAbiological_process
GO:0033555Multicellular organismal response to stressIEAbiological_process
GO:0033754Indoleamine 2,3-dioxygenase activityIEAmolecular_function
GO:0034276Kynurenic acid biosynthetic processIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0036269Swimming behaviorIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046007Negative regulation of activated T cell proliferationIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0070233Negative regulation of T cell apoptotic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06473344100.35308462440.54856693501.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2259840230
GSE13712_SHEARUp0.5995298556
GSE13712_STATICUp2.0383361177
GSE19018Up0.2602995581
GSE19899_A1Up0.0461080732
GSE19899_A2Down-0.0705308932
PubMed_21979375_A1Up0.1015731467
PubMed_21979375_A2Down-0.0447706314
GSE35957Down-0.1280290017
GSE36640Up0.3653130176
GSE54402Up0.0451404418
GSE9593Down-0.2672414194
GSE43922Up0.0171987162
GSE24585Down-0.3148936992
GSE37065Up2.1323437944
GSE28863_A1Down-0.4950395745
GSE28863_A2Up0.2633938915
GSE28863_A3Down-0.0194755941
GSE28863_A4Down-0.3086227532
GSE48662Up0.7991856355

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.