HCSGD entry for IMPDH2
1. General information
| Official gene symbol | IMPDH2 |
|---|---|
| Entrez ID | 3615 |
| Gene full name | IMP (inosine 5'-monophosphate) dehydrogenase 2 |
| Other gene symbols | IMPD2 IMPDH-II |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IDA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0003938 | IMP dehydrogenase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005778 | Peroxisomal membrane | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006144 | Purine nucleobase metabolic process | TAS | biological_process |
| GO:0006164 | Purine nucleotide biosynthetic process | IEA | biological_process |
| GO:0006177 | GMP biosynthetic process | IEA | biological_process |
| GO:0009168 | Purine ribonucleoside monophosphate biosynthetic process | TAS | biological_process |
| GO:0030554 | Adenyl nucleotide binding | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9667233806 | 0.0139373162 | 0.9999902473 | 0.2324936829 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2307685224 |
| GSE13712_SHEAR | Down | -0.3075136292 |
| GSE13712_STATIC | Down | -0.0660598829 |
| GSE19018 | Down | -0.3000614286 |
| GSE19899_A1 | Down | -0.2852610729 |
| GSE19899_A2 | Down | -0.3310184745 |
| PubMed_21979375_A1 | Down | -0.7738629734 |
| PubMed_21979375_A2 | Down | -0.2297306940 |
| GSE35957 | Down | -0.4617662284 |
| GSE36640 | Down | -0.8233529751 |
| GSE54402 | Down | -0.1149409819 |
| GSE9593 | Down | -0.4746090443 |
| GSE43922 | Down | -0.0766995650 |
| GSE24585 | Up | 0.2140721863 |
| GSE37065 | Down | -0.7306474830 |
| GSE28863_A1 | Up | 0.7119627799 |
| GSE28863_A2 | Up | 0.1588726801 |
| GSE28863_A3 | Down | -0.0254379652 |
| GSE28863_A4 | Down | -0.1710314509 |
| GSE48662 | Down | -0.6846445000 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| Mycophenolate mofetil | DB00688 | APRD01602 |
| Ribavirin | DB00811 | APRD00081 | EXPT02825 | DB01693 |
| Mycophenolic acid | DB01024 | APRD01603 | EXPT02208 |
| Selenazole-4-Carboxyamide-Adenine Dinucleotide | DB03070 | EXPT02840 |
| 6-Chloropurine Riboside, 5'-Monophosphate | DB03948 | EXPT01004 |
| Inosinic Acid | DB04566 | EXPT01874 |
| VX-148 | DB06103 | - |
| Mercaptopurine | DB01033 | APRD01096 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT006255 | Luciferase reporter assay | Functional MTI | 22301190 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031800 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032398 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-33b-5p | MIMAT0003301 | MIRT039581 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039630 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042838 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-5p | MIMAT0000731 | MIRT043988 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT046109 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046295 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23a-3p | MIMAT0000078 | MIRT050406 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050763 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
