HCSGD entry for IL15

1. General information

Official gene symbolIL15
Entrez ID3600
Gene full nameinterleukin 15
Other gene symbolsIL-15
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001779Natural killer cell differentiationIEAbiological_process
GO:0001866NK T cell proliferationIEAbiological_process
GO:0005125Cytokine activityIEAmolecular_function
GO:0005126Cytokine receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionNAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005768EndosomeTAScellular_component
GO:0005794Golgi apparatusTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007568AgingIEAbiological_process
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0014732Skeletal muscle atrophyIEAbiological_process
GO:0016020MembraneTAScellular_component
GO:0030212Hyaluronan metabolic processIEAbiological_process
GO:0032740Positive regulation of interleukin-17 productionIDAbiological_process
GO:0032819Positive regulation of natural killer cell proliferationIEAbiological_process
GO:0032825Positive regulation of natural killer cell differentiationIEAbiological_process
GO:0034105Positive regulation of tissue remodelingICbiological_process
GO:0042102Positive regulation of T cell proliferationIEAbiological_process
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinIEAbiological_process
GO:0045062Extrathymic T cell selectionIEAbiological_process
GO:0045580Regulation of T cell differentiationIEAbiological_process
GO:0048469Cell maturationIEAbiological_process
GO:0048535Lymph node developmentIEAbiological_process
GO:0048662Negative regulation of smooth muscle cell proliferationIEAbiological_process
GO:0050691Regulation of defense response to virus by hostIEAbiological_process
GO:0050729Positive regulation of inflammatory responseICbiological_process
GO:0050778Positive regulation of immune responseIEAbiological_process
GO:0071305Cellular response to vitamin DIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95679587780.00192994570.99999024730.0846848435

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1971718086
GSE13712_SHEARDown-0.1808977797
GSE13712_STATICUp0.1715331475
GSE19018Up0.2517450662
GSE19899_A1Down-0.6393808197
GSE19899_A2Down-3.2281972553
PubMed_21979375_A1Down-1.5963216186
PubMed_21979375_A2Down-4.2484845528
GSE35957Down-0.5652922309
GSE36640Down-0.6045107888
GSE54402Down-1.6265171534
GSE9593Down-0.1287428298
GSE43922Down-0.3572316487
GSE24585Down-0.0933767437
GSE37065Up0.1266260413
GSE28863_A1Down-0.1591529819
GSE28863_A2Up0.2787076403
GSE28863_A3Down-0.1031148632
GSE28863_A4Down-0.0651383934
GSE48662Down-0.1571202848

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024918MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026532MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

28123872IL-15 enhances the antitumor effect of human antigen-specific CD8+ T cells by cellular senescence delay
28123872Optimal expansion protocols for adoptive human T-cell therapy often include interleukin (IL)-15; however, the mechanism by which IL-15 improves the in vivo antitumor effect of T cells remains to be elucidated
28123872Using human T cells generated from HLA-A2+ donors against novel T-cell epitopes derived from the human U266 myeloma cell line Ig light chain V-region (idiotype) as a model, we found that T cells cultured with IL-15 provided superior resistance to tumor growth in vivo, compared with IL-2, after adoptive transfer into immunodeficient hosts
28123872This effect of IL-15 was associated with delayed/reversed senescence in tumor antigen-specific memory CD8+ T cells mediated through downregulation of P21WAF1, P16INK4a, and P53 expression
28123872Compared to IL-2, IL-15 stimulation dramatically activated JAK3-STAT5 signaling and inhibited the expression of DNA damage genes
28123872Thus, our study elucidates a new mechanism for IL-15 in the regulation of STAT signaling pathways and CD8+ T-cell senescence
26857736IL-15 boosts the function and migration of human terminally differentiated CD8+ T cells by inducing a unique gene signature
26857736Human CCR7(low)CD45RA(high) effector memory CD8(+) T cells (terminally differentiated TEMRA) are reportedly a functionally compromised population with characteristics of cellular senescence when examined ex vivo Although their frequencies are increased in elderly subjects in association with declined immune competence, however, it remains unclear whether their impaired functions can be reversed so that they contribute to immune responses in vivo Here, I show that, in contrast to TCR stimulation, stimulation of TEMRA with IL-15 induced a unique transcriptional signature, promoted IFN-gamma production and cell cycle entry, and reduced chemotaxis toward sphingosine-1-phosphate (S1P)
26857736These results suggest that TEMRA act as functional effector T cells in non-lymphoid tissues when IL-15 is abundant and that IL-15 treatment may be beneficial in enhancing vaccine efficacy in elderly people
21635686IL-15 preferentially enhances functional properties and antigen-specific responses of CD4+CD28(null) compared to CD4+CD28+ T cells
21635686Recent studies have shown that IL-15 does in fact play an appreciable role in CD4 memory T cells under physiological conditions
21635686We found that treatment with IL-15 increased the frequency of elderly CD4+CD28(null) T cells by the preferential proliferation of these cells compared to CD4+CD28+ T cells
21635686IL-15 induced an activated phenotype in CD4+CD28(null) T cells
21635686Moreover, pretreatment of CD4+CD28(null) T cells with IL-15 displayed a synergistic effect on the IFN-gamma production in CMV-specific responses, which was not observed in CD4+CD28+ T cells
21635686IL-15 could play a role enhancing the effector response of CD4+CD28(null) T cells against their specific chronic antigens
15882354Interestingly, in vitro culture of these two subsets with interleukin-15 showed that similar gene expression changes occurred in both subsets
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