HCSGD entry for IL12B

1. General information

Official gene symbolIL12B
Entrez ID3593
Gene full nameinterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
Other gene symbolsCLMF CLMF2 IL-12B NKSF NKSF2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001916Positive regulation of T cell mediated cytotoxicityISSbiological_process
GO:0002230Positive regulation of defense response to virus by hostIDA ISSbiological_process
GO:0002323Natural killer cell activation involved in immune responseIEAbiological_process
GO:0002827Positive regulation of T-helper 1 type immune responseIDA ISSbiological_process
GO:0002860Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetIDAbiological_process
GO:0002862Negative regulation of inflammatory response to antigenic stimulusIEAbiological_process
GO:0004896Cytokine receptor activityIEAmolecular_function
GO:0005125Cytokine activityIDAmolecular_function
GO:0005143Interleukin-12 receptor bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0007050Cell cycle arrestIDAbiological_process
GO:0008083Growth factor activityIDAmolecular_function
GO:0010224Response to UV-BIDAbiological_process
GO:0010535Positive regulation of activation of JAK2 kinase activityIDAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016477Cell migrationIDAbiological_process
GO:0019233Sensory perception of painIEAbiological_process
GO:0019953Sexual reproductionTASbiological_process
GO:0030101Natural killer cell activationIDAbiological_process
GO:0032693Negative regulation of interleukin-10 productionIMPbiological_process
GO:0032700Negative regulation of interleukin-17 productionIDAbiological_process
GO:0032725Positive regulation of granulocyte macrophage colony-stimulating factor productionIDAbiological_process
GO:0032729Positive regulation of interferon-gamma productionIDAbiological_process
GO:0032733Positive regulation of interleukin-10 productionIDA TASbiological_process
GO:0032735Positive regulation of interleukin-12 productionIDAbiological_process
GO:0032740Positive regulation of interleukin-17 productionIDAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIMPbiological_process
GO:0032816Positive regulation of natural killer cell activationIC IDAbiological_process
GO:0032819Positive regulation of natural killer cell proliferationIDAbiological_process
GO:0034105Positive regulation of tissue remodelingICbiological_process
GO:0034393Positive regulation of smooth muscle cell apoptotic processIDAbiological_process
GO:0042035Regulation of cytokine biosynthetic processTASbiological_process
GO:0042088T-helper 1 type immune responseTASbiological_process
GO:0042093T-helper cell differentiationIDAbiological_process
GO:0042095Interferon-gamma biosynthetic processTASbiological_process
GO:0042102Positive regulation of T cell proliferationIDAbiological_process
GO:0042104Positive regulation of activated T cell proliferationIDAbiological_process
GO:0042164Interleukin-12 alpha subunit bindingIEAmolecular_function
GO:0042346Positive regulation of NF-kappaB import into nucleusTASbiological_process
GO:0042510Regulation of tyrosine phosphorylation of Stat1 proteinIDAbiological_process
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinIDAbiological_process
GO:0042520Positive regulation of tyrosine phosphorylation of Stat4 proteinIDAbiological_process
GO:0042523Positive regulation of tyrosine phosphorylation of Stat5 proteinIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0042832Defense response to protozoanIEAbiological_process
GO:0043382Positive regulation of memory T cell differentiationISSbiological_process
GO:0043514Interleukin-12 complexIDAcellular_component
GO:0044130Negative regulation of growth of symbiont in hostIEAbiological_process
GO:0045078Positive regulation of interferon-gamma biosynthetic processTASbiological_process
GO:0045519Interleukin-23 receptor bindingIDAmolecular_function
GO:0045672Positive regulation of osteoclast differentiationIDAbiological_process
GO:0045785Positive regulation of cell adhesionIDAbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0048662Negative regulation of smooth muscle cell proliferationIDAbiological_process
GO:0050671Positive regulation of lymphocyte proliferationIDAbiological_process
GO:0050729Positive regulation of inflammatory responseICbiological_process
GO:0050829Defense response to Gram-negative bacteriumIDAbiological_process
GO:0051135Positive regulation of NK T cell activationIC IDAbiological_process
GO:0051142Positive regulation of NK T cell proliferationIDAbiological_process
GO:0051607Defense response to virusIEAbiological_process
GO:0070743Interleukin-23 complexIDAcellular_component
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071346Cellular response to interferon-gammaIEAbiological_process
GO:2000318Positive regulation of T-helper 17 type immune responseISSbiological_process
GO:2000330Positive regulation of T-helper 17 cell lineage commitmentISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57264272630.70165067440.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0425389896
GSE13712_SHEARUp0.0133292108
GSE13712_STATICUp0.0363654472
GSE19018Up0.0753305961
GSE19899_A1Up0.3414435803
GSE19899_A2Down-0.1872510555
PubMed_21979375_A1Down-0.2357779089
PubMed_21979375_A2Down-0.1127315433
GSE35957Down-0.2081854000
GSE36640Down-0.2359896744
GSE54402Down-0.0473136497
GSE9593Down-0.0710744490
GSE43922Up0.0360076837
GSE24585Up0.1936412233
GSE37065Up0.0448242938
GSE28863_A1Down-0.0027851419
GSE28863_A2Up0.0880664811
GSE28863_A3Up0.1657727771
GSE28863_A4Up0.0789622964
GSE48662Down-0.0561873066

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

5-Mercapto-2-Nitro-Benzoic AcidDB02763 EXPT02201
BriakinumabDB05459 -
UstekinumabDB05679 -
humanized SMART Anti-IL-12 AntibodyDB05848 -
UstekinumabDB05679 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.