HCSGD entry for IL10

1. General information

Official gene symbolIL10
Entrez ID3586
Gene full nameinterleukin 10
Other gene symbolsCSIF GVHDS IL-10 IL10A TGIF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002237Response to molecule of bacterial originIDAbiological_process
GO:0002740Negative regulation of cytokine secretion involved in immune responseIDAbiological_process
GO:0002875Negative regulation of chronic inflammatory response to antigenic stimulusIEAbiological_process
GO:0002904Positive regulation of B cell apoptotic processIDAbiological_process
GO:0005125Cytokine activityNASmolecular_function
GO:0005141Interleukin-10 receptor bindingNASmolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0006954Inflammatory responseIDAbiological_process
GO:0007253Cytoplasmic sequestering of NF-kappaBNASbiological_process
GO:0007267Cell-cell signalingICbiological_process
GO:0008083Growth factor activityNASmolecular_function
GO:0010468Regulation of gene expressionIDAbiological_process
GO:0014823Response to activityIEAbiological_process
GO:0014854Response to inactivityIEAbiological_process
GO:0030097HemopoiesisTASbiological_process
GO:0030183B cell differentiationNASbiological_process
GO:0030595Leukocyte chemotaxisTASbiological_process
GO:0030886Negative regulation of myeloid dendritic cell activationIEAbiological_process
GO:0030889Negative regulation of B cell proliferationIDAbiological_process
GO:0032689Negative regulation of interferon-gamma productionIEAbiological_process
GO:0032695Negative regulation of interleukin-12 productionIEAbiological_process
GO:0032715Negative regulation of interleukin-6 productionIDAbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIEAbiological_process
GO:0032800Receptor biosynthetic processIDAbiological_process
GO:0032868Response to insulinIEAbiological_process
GO:0034465Response to carbon monoxideIEAbiological_process
GO:0042092Type 2 immune responseTASbiological_process
GO:0042100B cell proliferationNASbiological_process
GO:0042130Negative regulation of T cell proliferationNASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042536Negative regulation of tumor necrosis factor biosynthetic processIEAbiological_process
GO:0042742Defense response to bacteriumIEAbiological_process
GO:0043066Negative regulation of apoptotic processNASbiological_process
GO:0044130Negative regulation of growth of symbiont in hostIEAbiological_process
GO:0045019Negative regulation of nitric oxide biosynthetic processIEAbiological_process
GO:0045191Regulation of isotype switchingNASbiological_process
GO:0045347Negative regulation of MHC class II biosynthetic processTASbiological_process
GO:0045348Positive regulation of MHC class II biosynthetic processIEAbiological_process
GO:0045355Negative regulation of interferon-alpha biosynthetic processNASbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0050715Positive regulation of cytokine secretionIDAbiological_process
GO:0051045Negative regulation of membrane protein ectodomain proteolysisIDAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0051384Response to glucocorticoidIDAbiological_process
GO:0051930Regulation of sensory perception of painIEAbiological_process
GO:0060670Branching involved in labyrinthine layer morphogenesisIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideNASbiological_process
GO:0071392Cellular response to estradiol stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94261988150.25656823450.99999024730.9714554229

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1196742806
GSE13712_SHEARDown-0.3505377665
GSE13712_STATICUp0.0950823294
GSE19018Down-0.0071378885
GSE19899_A1Up0.0076367389
GSE19899_A2Up0.1072963390
PubMed_21979375_A1Down-0.1208800726
PubMed_21979375_A2Down-0.1615560547
GSE35957Down-0.1634062209
GSE36640Down-0.0439953434
GSE54402Up0.1130404301
GSE9593Down-0.1852493973
GSE43922Up0.0104720977
GSE24585Up0.0688123508
GSE37065Down-0.0709563884
GSE28863_A1Down-0.3142742930
GSE28863_A2Down-0.2498542253
GSE28863_A3Up0.2409523287
GSE28863_A4Up0.0421476719
GSE48662Down-0.0205871698

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AV411DB05066 -
CRx-139DB05744 -
LLL-3348DB05771 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-106a-5pMIMAT0000103MIRT005082Luciferase reporter assay//qRT-PCRFunctional MTI19307576
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 11 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23853351The increased susceptibility of immune inflammatory response, morbidity and mortality in the elderly is often associated with decreased frequencies of anti-inflammatory factor IL-10 -1082G allele, TNF-beta1 haplotype cnd10T/C, cnd25G/G, -988C/C, -800G/A, low proinflammatory fator TNFa level related extended TNF-A genotype -1031C/C, -863C/A, -857C/C, IL-6-174 CC and IFN-gamma+874 T allele as well
21680897Telomere disruption increased monocyte secretion of monocyte chemoattractant protein-1, IL-6, and IL-1beta and oxidative burst, similar to that seen in coronary artery disease patients, and lymphocyte secretion of IL-2 and reduced lymphocyte IL-10
21300823These subsets exhibited differences in suppressive capacity, ability to secrete IL-10 and IL-17, Foxp3 gene methylation, cellular senescence, and frequency in neonatal and adult blood
20038483IL-7 protects both B and T lymphocytes, but IL-2, IL-10, keratinocyte growth factor, thymic stromal lymphopoietin, as well as leptin and growth hormone also have a stimulatory effect on thymopoiesis
19802007JAK1/STAT-activating ligands, interleukin 10 (IL10), IL20, IL24, interferon gamma (IFNgamma), IFNbeta and IL6, were also expressed by senescent cells, supporting autocrine/paracrine activation of JAK1/STAT
17785865Correspondingly, caregivers had significantly lower T cell proliferation but higher production of immune-regulatory cytokines (TNF-alpha and IL-10) than controls in response to stimulation in vitro
17199788Serum oxidized low-density lipoprotein (ox-LDL), tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) were also measured in both groups by ELISA
17117905The presence of senescent cells was associated with high levels of IL-10 and IFN-Y in plasma and urine
11872952In situ activated intestinal T cells expanded in vitro--without addition of antigen--produce IFN-gamma and IL-10 and preserve their function during growth
11872952OBJECTIVE: The balance between mucosal CD4+ T cells producing IFN-gamma or IL-10 is essential in the maintenance of intestinal homeostasis
11872952We aimed to investigate how in situ activated T cells were expanded in vitro according to a new cell culture protocol and if it selected for continuous clonal CD4+ T cells capable of producing mainly IFN-gamma or IL-10
11830522IL-10 and IL-4 mRNA expression was not significantly different from control samples
7540646Anti-CD3-stimulated T cells from young mice exhibited increased production of interleukin (IL)-2 and decreased production of interferon-gamma and IL-10 compared with old mice
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