HCSGD entry for IL6R

1. General information

Official gene symbolIL6R
Entrez ID3570
Gene full nameinterleukin 6 receptor
Other gene symbolsCD126 IL-6R-1 IL-6RA IL6Q IL6RA IL6RQ gp80
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002384Hepatic immune responseTASbiological_process
GO:0002446Neutrophil mediated immunityICbiological_process
GO:0002548Monocyte chemotaxisICbiological_process
GO:0002690Positive regulation of leukocyte chemotaxisIC TASbiological_process
GO:0004896Cytokine receptor activityIEAmolecular_function
GO:0004897Ciliary neurotrophic factor receptor activityIMPmolecular_function
GO:0004915Interleukin-6 receptor activityIDAmolecular_function
GO:0005138Interleukin-6 receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIDA TAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005896Interleukin-6 receptor complexIDAcellular_component
GO:0006953Acute-phase responseTASbiological_process
GO:0008284Positive regulation of cell proliferationIDA IMPbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010536Positive regulation of activation of Janus kinase activityIDAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016324Apical plasma membraneIDAcellular_component
GO:0019221Cytokine-mediated signaling pathwayIDAbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0019981Interleukin-6 bindingIPImolecular_function
GO:0031018Endocrine pancreas developmentIC IMPbiological_process
GO:0032717Negative regulation of interleukin-8 productionIEPbiological_process
GO:0032722Positive regulation of chemokine productionIDAbiological_process
GO:0032755Positive regulation of interleukin-6 productionIDAbiological_process
GO:0032966Negative regulation of collagen biosynthetic processIDAbiological_process
GO:0034097Response to cytokineIDAbiological_process
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinIMPbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043410Positive regulation of MAPK cascadeIDAbiological_process
GO:0045669Positive regulation of osteoblast differentiationTASbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIDAbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050829Defense response to Gram-negative bacteriumIEPbiological_process
GO:0050830Defense response to Gram-positive bacteriumIEPbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0070102Interleukin-6-mediated signaling pathwayIMPbiological_process
GO:0070119Ciliary neurotrophic factor bindingIPImolecular_function
GO:0070120Ciliary neurotrophic factor-mediated signaling pathwayIMPbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02322484710.91075933290.36257485171.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1172477057
GSE13712_SHEARDown-0.6683088459
GSE13712_STATICDown-0.1880480491
GSE19018Down-0.1201696999
GSE19899_A1Down-0.0476501994
GSE19899_A2Up0.9695251012
PubMed_21979375_A1Up0.9473592338
PubMed_21979375_A2Up1.4941733022
GSE35957Down-0.2312059945
GSE36640Up1.0934809637
GSE54402Up0.3004412279
GSE9593Up0.0251808580
GSE43922Up0.0621083288
GSE24585Up0.0117550827
GSE37065Up0.3172277735
GSE28863_A1Up0.6689803733
GSE28863_A2Up0.6413415743
GSE28863_A3Down-0.0004266561
GSE28863_A4Down-0.0613116469
GSE48662Up0.1169560822

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TocilizumabDB06273 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT006541ELISA//Flow//Immunohistochemistry//Immunoprecipitaion//In situ hybridization//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI22153071
hsa-miR-23a-3pMIMAT0000078MIRT005528GFP reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI20698883
hsa-miR-98-5pMIMAT0000096MIRT027423MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-21-5pMIMAT0000076NAhsa-miR-2117991735
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24047696In analogy to senescence, EGFR-induced activation of mTOR also induced IL-6R expression and sIL-6R generation
24047696Our data suggest that mTOR serves as a central molecular switch to facilitate cellular IL-6 classic and trans-signaling via IL-6R upregulation with direct implications for cellular senescence and tumor development
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