HCSGD entry for SHROOM2

1. General information

Official gene symbolSHROOM2
Entrez ID357
Gene full nameshroom family member 2
Other gene symbolsAPXL HSAPXL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000902Cell morphogenesisIDA IEA ISSbiological_process
GO:0002089Lens morphogenesis in camera-type eyeISSbiological_process
GO:0003779Actin bindingISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005856CytoskeletonISScellular_component
GO:0005874MicrotubuleIEAcellular_component
GO:0005886Plasma membraneISScellular_component
GO:0005913Cell-cell adherens junctionISScellular_component
GO:0005923Tight junctionISScellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0006810TransportTASbiological_process
GO:0006812Cation transportTASbiological_process
GO:0007420Brain developmentISSbiological_process
GO:0008013Beta-catenin bindingISSmolecular_function
GO:0008057Eye pigment granule organizationISSbiological_process
GO:0015280Ligand-gated sodium channel activityTASmolecular_function
GO:0015672Monovalent inorganic cation transportTASbiological_process
GO:0016324Apical plasma membraneISScellular_component
GO:0016477Cell migrationISSbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030001Metal ion transportTASbiological_process
GO:0030835Negative regulation of actin filament depolymerizationIEAbiological_process
GO:0030864Cortical actin cytoskeletonIDA ISScellular_component
GO:0031941Filamentous actinIEAcellular_component
GO:0032401Establishment of melanosome localizationIEA ISSbiological_process
GO:0032438Melanosome organizationISSbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0035725Sodium ion transmembrane transportTASbiological_process
GO:0043010Camera-type eye developmentISSbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043296Apical junction complexIEAcellular_component
GO:0043482Cellular pigment accumulationISSbiological_process
GO:0043583Ear developmentISSbiological_process
GO:0045176Apical protein localizationIEA ISSbiological_process
GO:0045217Cell-cell junction maintenanceIEAbiological_process
GO:0048593Camera-type eye morphogenesisISSbiological_process
GO:0051015Actin filament bindingIEA ISSmolecular_function
GO:0051017Actin filament bundle assemblyISSbiological_process
GO:0055085Transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97811592260.00140809240.99999024730.0725291585

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0503123096
GSE13712_SHEARDown-1.5232317759
GSE13712_STATICDown-1.0738151143
GSE19018Down-0.6817454677
GSE19899_A1Down-0.3559447787
GSE19899_A2Down-2.0378434008
PubMed_21979375_A1Down-0.8083740510
PubMed_21979375_A2Down-0.0349701400
GSE35957Down-1.9038984203
GSE36640Down-3.2806234411
GSE54402Down-1.3470601905
GSE9593Down-0.0598550893
GSE43922Up0.0849963573
GSE24585Down-0.0974335941
GSE37065Down-0.2610776783
GSE28863_A1Down-0.0535308865
GSE28863_A2Down-0.1293628463
GSE28863_A3Up0.1871974819
GSE28863_A4Up0.0864103662
GSE48662Up0.1374980415

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-296-3pMIMAT0004679MIRT038423CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.