HCSGD entry for IL4

1. General information

Official gene symbolIL4
Entrez ID3565
Gene full nameinterleukin 4
Other gene symbolsBCGF-1 BCGF1 BSF-1 BSF1 IL-4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002227Innate immune response in mucosaIEAbiological_process
GO:0002296T-helper 1 cell lineage commitmentIEAbiological_process
GO:0002674Negative regulation of acute inflammatory responseIEAbiological_process
GO:0002677Negative regulation of chronic inflammatory responseIEAbiological_process
GO:0005125Cytokine activityIEAmolecular_function
GO:0005136Interleukin-4 receptor bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceTAScellular_component
GO:0006935ChemotaxisTASbiological_process
GO:0006955Immune responseTASbiological_process
GO:0006968Cellular defense responseTASbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0008083Growth factor activityNASmolecular_function
GO:0008203Cholesterol metabolic processISSbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0010155Regulation of proton transportIEAbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0030183B cell differentiationTASbiological_process
GO:0030890Positive regulation of B cell proliferationISSbiological_process
GO:0031296B cell costimulationIEAbiological_process
GO:0032733Positive regulation of interleukin-10 productionIEAbiological_process
GO:0032736Positive regulation of interleukin-13 productionIDAbiological_process
GO:0034097Response to cytokineIEAbiological_process
GO:0035745T-helper 2 cell cytokine productionIDAbiological_process
GO:0042092Type 2 immune responseTASbiological_process
GO:0042102Positive regulation of T cell proliferationISSbiological_process
GO:0042104Positive regulation of activated T cell proliferationIEAbiological_process
GO:0042325Regulation of phosphorylationISSbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042523Positive regulation of tyrosine phosphorylation of Stat5 proteinIEAbiological_process
GO:0042832Defense response to protozoanIEAbiological_process
GO:0043031Negative regulation of macrophage activationIEAbiological_process
GO:0043066Negative regulation of apoptotic processISSbiological_process
GO:0045019Negative regulation of nitric oxide biosynthetic processIEAbiological_process
GO:0045064T-helper 2 cell differentiationIEAbiological_process
GO:0045080Positive regulation of chemokine biosynthetic processIEAbiological_process
GO:0045189Connective tissue growth factor biosynthetic processTASbiological_process
GO:0045191Regulation of isotype switchingTASbiological_process
GO:0045348Positive regulation of MHC class II biosynthetic processISSbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045582Positive regulation of T cell differentiationIDAbiological_process
GO:0045671Negative regulation of osteoclast differentiationISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0048295Positive regulation of isotype switching to IgE isotypesISSbiological_process
GO:0048304Positive regulation of isotype switching to IgG isotypesISSbiological_process
GO:0050776Regulation of immune responseISSbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIEAbiological_process
GO:0071288Cellular response to mercury ionIEAbiological_process
GO:0097028Dendritic cell differentiationIDAbiological_process
GO:0097192Extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
GO:2000320Negative regulation of T-helper 17 cell differentiationIEAbiological_process
GO:2001237Negative regulation of extrinsic apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89394086850.56309047910.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0598011854
GSE13712_SHEARDown-0.0810395686
GSE13712_STATICDown-0.0267508844
GSE19018Down-0.0294303844
GSE19899_A1Down-0.0120563755
GSE19899_A2Up0.0263924711
PubMed_21979375_A1Up0.4067235002
PubMed_21979375_A2Up0.2175743852
GSE35957Up0.1000003129
GSE36640Down-0.0338285367
GSE54402Up0.0568585129
GSE9593Up0.0391175974
GSE43922Up0.0133152163
GSE24585Up0.1698634287
GSE37065Down-0.0794671872
GSE28863_A1Down-0.1590180587
GSE28863_A2Down-0.1330252836
GSE28863_A3Up0.0810719016
GSE28863_A4Down-0.3315621392
GSE48662Down-0.0104912539

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018167MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 13 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26434982We found not only an age-dependent increase in expression of several pro-inflammatory mediators, but also activation of a strong anti-inflammatory response involving enhanced IL4/IL10 expression and immune skewing toward a Th2 response
25989853By contrast, in consequence of impaired nuclear translocation of phospho-STAT6, genes involved in IL-4 induced alternative activation were strongly downregulated
25989853Functionally, impaired actin dynamics resulted in reduced NO secretion and reduced release of TNFalpha and IL-6 from LPS-stimulated microglia and of IGF-1 from IL-4 stimulated microglia
25466460The SPR biosensor also shows specificity for IGFBP7 compared to that for biologically relevant interleukin (IL) derivatives including IL4, IL23, IL29, and IFG1
24434012Multiplex analysis revealed that multiple cytokines are increased in BPH, including GM-CSF, IL-1alpha, and IL-4, and that these are also increased in senescent prostatic epithelial cells in vitro
23935100Interleukin (IL)-4, originally identified as a lymphocyte growth factor, can directly inhibit growth of certain tumor cell types
23935100Both of these molecules were activated by 10 min after IL-4 treatment, and inhibition of their activity or expression prevented growth suppression and cellular senescence induced by IL-4
18206261TGF-beta1 and IL-4 downregulate human papillomavirus-16 oncogene expression but have differential effects on the malignant phenotype of cervical carcinoma cells
18206261In a previous study, we demonstrated the inhibitory activity of several cytokines on the HPV-16 long control region (LCR)-driven transcription; among these, IL-4 was reported as a LCR inhibitor for the first time and proposed as a candidate for further studies
18206261Here, we addressed the question of whether IL-4 represses HPV-16 oncogene transcription and exerts antitumor activity in HPV-16 positive cervical carcinoma cell lines
18206261Results indicated that downregulation of E6 and E7 levels by IL-4 in CaSki cells is weaker than that exerted by TGF-beta1, a known LCR inhibitor, although both cytokines are equally active in suppressing LCR-driven transcriptional activity in a reporter cell line
16821141In inflamed portal tracts of PBC, CD4+ T cells of Th1 type expressing IFN-gamma or CXCR3 are aggregated and more commonly detected around injured bile ducts than Th2-type CD4+ T cells expressing IL-4 or CCR4, indicating that Th1-dominant cellular immunity plays a more-prominent role in recruitment of memory T-cell subsets in PBC and may be responsible for the progressive bile duct damage
15876845After culture in vitro, these cells shown increase susceptibility to undergoing spontaneous apoptosis, that is enhanced by IL-4 and prevented by IL-1beta or LPS
15685514Expression of p53, CD14/CD16, and intracellular cytokine production (interleukin-1beta [IL-1beta], IL-6, and IL-4) was evaluated by means of flow cytometry using specific antibodies
15685514RESULTS: Features of senescence were found in a subpopulation of mononuclear cells: (1) accelerated telomere shortening, (2) increased p53 expression, (3) CD14dim/CD16bright expression, and (4) cytokine overproduction (IL-1beta, IL-6, and IL-4)
11872952METHODS: T cell cultures were established from colonic biopsy specimens of 27 patients with Crohn's disease and from 10 healthy controls in a medium supplemented with IL-2 and IL-4 but without addition of exogenous antigen or mitogen
11830522IL-10 and IL-4 mRNA expression was not significantly different from control samples
9691202However, continuous T lymphocyte cell lines can often be established from chronic inflammatory skin diseases when the culture medium is supplemented with IL-2 and IL-4 but without antigen and accessory cells added
9691202Withdrawal of either IL-2 or IL-4 results in cell growth arrest concomitant with down-regulation of telomerase activity
1477651The role of IL-4 in human myeloid leukemia: stimulation of RNA synthesis and transduction of differentiation signals through an IL-4 receptor leads to functional and HLA positive HL-60 cells
1477651One example, that is the subject of this study, is the presence of the interleukin-4 (IL-4) receptor on the surface of the human HL-60 myeloid leukemia cell line
1477651The presence of such a receptor, that at first seems to be a simple genetic misprogramming, has an unusual biological function: It serves as a bridge to link the B cell growth factor IL-4 in order to transduce a number of differentiation signals in this M2 acute myeloid leukemia (AML) population
1477651Daily administration of low IL-4 dose yields proliferative senescent cells that exhibit 66% of growth inhibition in a 5-day tritiated thymidine incorporation assay
1477651Cellular function is also affected positively since phagocytosis of latex beads increases considerably after IL-4 treatment
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