HCSGD entry for IL3
1. General information
| Official gene symbol | IL3 |
|---|---|
| Entrez ID | 3562 |
| Gene full name | interleukin 3 (colony-stimulating factor, multiple) |
| Other gene symbols | IL-3 MCGF MULTI-CSF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005135 | Interleukin-3 receptor binding | TAS | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | ISS | cellular_component |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0007399 | Nervous system development | TAS | biological_process |
| GO:0008083 | Growth factor activity | IEA | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | ISS | biological_process |
| GO:0035162 | Embryonic hemopoiesis | IDA | biological_process |
| GO:0042523 | Positive regulation of tyrosine phosphorylation of Stat5 protein | IDA | biological_process |
| GO:0045740 | Positive regulation of DNA replication | IDA | biological_process |
| GO:0050731 | Positive regulation of peptidyl-tyrosine phosphorylation | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4106944645 | 0.9259956043 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1038911126 |
| GSE13712_SHEAR | Up | 0.1173307377 |
| GSE13712_STATIC | Down | -0.1132197842 |
| GSE19018 | Up | 0.2480449754 |
| GSE19899_A1 | Up | 0.0586000374 |
| GSE19899_A2 | Up | 0.2227496583 |
| PubMed_21979375_A1 | Up | 0.1381042701 |
| PubMed_21979375_A2 | Down | -0.1728025570 |
| GSE35957 | Down | -0.0180879855 |
| GSE36640 | Down | -0.0983314155 |
| GSE54402 | Up | 0.1078167061 |
| GSE9593 | Up | 0.0749500508 |
| GSE43922 | Up | 0.0137500677 |
| GSE24585 | Up | 0.0698023635 |
| GSE37065 | Down | -0.0708234393 |
| GSE28863_A1 | Up | 0.0990904195 |
| GSE28863_A2 | Up | 0.1552973384 |
| GSE28863_A3 | Up | 0.0158411848 |
| GSE28863_A4 | Up | 0.2508165923 |
| GSE48662 | Down | -0.0002876094 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Amlexanox | DB01025 | APRD00795 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029305 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20852063 | Among the cytokine combinations tested for the CD34(+) fraction, a combination (SFIb) consisting of stem cell factor (SCF), FMS-like tyrosine kinase 3 ligand, interleukin-3, and basic fibroblast growth factor resulted in a reproducible 64- to 1468-fold EPC expansion from various cord blood origins |
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