HCSGD entry for IL2RA

1. General information

Official gene symbolIL2RA
Entrez ID3559
Gene full nameinterleukin 2 receptor, alpha
Other gene symbolsCD25 IDDM10 IL2R TCGFR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002437Inflammatory response to antigenic stimulusIEAbiological_process
GO:0004911Interleukin-2 receptor activityIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0006924Activation-induced cell death of T cellsIEAbiological_process
GO:0006955Immune responseTASbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007219Notch signaling pathwayIEAbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0008283Cell proliferationTASbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0019976Interleukin-2 bindingIEAmolecular_function
GO:0042104Positive regulation of activated T cell proliferationIEAbiological_process
GO:0042130Negative regulation of T cell proliferationIEAbiological_process
GO:0045582Positive regulation of T cell differentiationIEAbiological_process
GO:0046013Regulation of T cell homeostatic proliferationIEAbiological_process
GO:0050687Negative regulation of defense response to virusIEAbiological_process
GO:0050728Negative regulation of inflammatory responseIEAbiological_process
GO:0050777Negative regulation of immune responseIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.58543651460.87163168950.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1782806349
GSE13712_SHEARUp0.0709495417
GSE13712_STATICUp0.0353001901
GSE19018Down-0.0533924135
GSE19899_A1Up0.0097066311
GSE19899_A2Up0.0571412437
PubMed_21979375_A1Up0.0240529332
PubMed_21979375_A2Down-0.0281682864
GSE35957Up0.1256221346
GSE36640Up0.1237614686
GSE54402Up0.0347338568
GSE9593Down-0.0512850865
GSE43922Up0.1897123954
GSE24585Up0.0597136906
GSE37065Up0.1065726368
GSE28863_A1Down-0.0795674762
GSE28863_A2Down-0.1118173092
GSE28863_A3Up0.2760511987
GSE28863_A4Up0.1391753560
GSE48662Up0.0396321177

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Denileukin diftitoxDB00004 BTD00084 | BIOD00084
AldesleukinDB00041 BTD00082 | BIOD00082
BasiliximabDB00074 BTD00073 | BIOD00073
DaclizumabDB00111 BTD00007 | BIOD00007

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20933612We will first detail T cell signaling through the T cell receptor (TCR), CD28 and IL-2 receptor (IL-2R) and then discuss the observed age-related alterations to these signaling pathways
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