HCSGD entry for IL1RN

1. General information

Official gene symbolIL1RN
Entrez ID3557
Gene full nameinterleukin 1 receptor antagonist
Other gene symbolsDIRA ICIL-1RA IL-1RN IL-1ra IL-1ra3 IL1F3 IL1RA IRAP MVCD4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001660Fever generationIEAbiological_process
GO:0001960Negative regulation of cytokine-mediated signaling pathwayIDAbiological_process
GO:0002439Chronic inflammatory response to antigenic stimulusIEAbiological_process
GO:0005149Interleukin-1 receptor bindingIDAmolecular_function
GO:0005150Interleukin-1, Type I receptor bindingIPImolecular_function
GO:0005151Interleukin-1, Type II receptor bindingIPImolecular_function
GO:0005152Interleukin-1 receptor antagonist activityIDA TASmolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005622IntracellularNAScellular_component
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006629Lipid metabolic processIEAbiological_process
GO:0006953Acute-phase responseIDAbiological_process
GO:0006955Immune responseNASbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0007613MemoryIEAbiological_process
GO:0010243Response to organonitrogen compoundIEAbiological_process
GO:0010469Regulation of receptor activityIDA TASbiological_process
GO:0014050Negative regulation of glutamate secretionIEAbiological_process
GO:0019752Carboxylic acid metabolic processIEAbiological_process
GO:0030073Insulin secretionIEAbiological_process
GO:0030336Negative regulation of cell migrationIEAbiological_process
GO:0031982VesicleIEAcellular_component
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0034115Negative regulation of heterotypic cell-cell adhesionIDAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043507Positive regulation of JUN kinase activityIEAbiological_process
GO:0045352Interleukin-1 Type I receptor antagonist activityIDAmolecular_function
GO:0045353Interleukin-1 Type II receptor antagonist activityIDAmolecular_function
GO:0045837Negative regulation of membrane potentialIEAbiological_process
GO:0051384Response to glucocorticoidIDAbiological_process
GO:0070670Response to interleukin-4IEAbiological_process
GO:1900116Extracellular negative regulation of signal transductionIDA TASbiological_process
GO:2000272Negative regulation of receptor activityIDA TASbiological_process
GO:2000660Negative regulation of interleukin-1-mediated signaling pathwayIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01032012460.98696757720.25845480491.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3036850921
GSE13712_SHEARDown-0.1016599290
GSE13712_STATICDown-0.0575891770
GSE19018Up0.1975072087
GSE19899_A1Up0.0734209710
GSE19899_A2Up0.8283137857
PubMed_21979375_A1Up2.3051481066
PubMed_21979375_A2Up0.1637695174
GSE35957Up0.0900484611
GSE36640Up0.1225356652
GSE54402Up1.3714515168
GSE9593Up0.0935369495
GSE43922Up0.2848589682
GSE24585Up0.0417540324
GSE37065Up1.4278169997
GSE28863_A1Up0.1286382276
GSE28863_A2Up0.1354123094
GSE28863_A3Up0.2038433162
GSE28863_A4Up0.0768050879
GSE48662Down-0.0020955094

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

RilonaceptDB06372 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-125b-5pMIMAT0000423NAhsa-miR-125b18056640
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25156255Mechanistically, we found that Gr-1(+) cells antagonize senescence in a paracrine manner by interfering with the senescence-associated secretory phenotype of the tumour through the secretion of interleukin-1 receptor antagonist (IL-1RA)
Entries Per Page
Displaying Page of