HCSGD entry for IL1R1
1. General information
| Official gene symbol | IL1R1 |
|---|---|
| Entrez ID | 3554 |
| Gene full name | interleukin 1 receptor, type I |
| Other gene symbols | CD121A D2S1473 IL-1R-alpha IL1R IL1RA P80 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002020 | Protease binding | IEA | molecular_function |
| GO:0004871 | Signal transducer activity | TAS | molecular_function |
| GO:0004888 | Transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0004908 | Interleukin-1 receptor activity | IDA IEA | molecular_function |
| GO:0004909 | Interleukin-1, Type I, activating receptor activity | IEA | molecular_function |
| GO:0005161 | Platelet-derived growth factor receptor binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0050727 | Regulation of inflammatory response | IEA | biological_process |
| GO:0070498 | Interleukin-1-mediated signaling pathway | IDA | biological_process |
| GO:0070555 | Response to interleukin-1 | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4635490369 | 0.0043663843 | 0.9999902473 | 0.1344256140 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2958236406 |
| GSE13712_SHEAR | Down | -2.4291106004 |
| GSE13712_STATIC | Down | -1.0015003508 |
| GSE19018 | Down | -1.5954301134 |
| GSE19899_A1 | Down | -0.4505533958 |
| GSE19899_A2 | Up | 0.0623046539 |
| PubMed_21979375_A1 | Down | -0.6897506541 |
| PubMed_21979375_A2 | Down | -0.4221190807 |
| GSE35957 | Up | 0.5113552969 |
| GSE36640 | Up | 0.0262392579 |
| GSE54402 | Down | -0.3373656134 |
| GSE9593 | Up | 0.5234132205 |
| GSE43922 | Down | -0.3679559728 |
| GSE24585 | Up | 0.2872156958 |
| GSE37065 | Up | 0.0780435144 |
| GSE28863_A1 | Up | 0.8923443082 |
| GSE28863_A2 | Up | 1.0600959099 |
| GSE28863_A3 | Down | -0.3112943987 |
| GSE28863_A4 | Down | -0.5837466396 |
| GSE48662 | Down | -0.0584437300 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-197-3p | MIMAT0000227 | MIRT004217 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023115 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024405 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026961 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 28036343 | Results of the elastic net regression showed weak relationships between IL-1Ra and FTC-triphosphate and deoxyadenosine triphosphate exposures, and MIP-1beta, age and TFV-diphosphate exposures |
| 25156255 | Mechanistically, we found that Gr-1(+) cells antagonize senescence in a paracrine manner by interfering with the senescence-associated secretory phenotype of the tumour through the secretion of interleukin-1 receptor antagonist (IL-1RA) |
| 19805069 | An IL-1 receptor (IL1R) antagonist, neutralizing IL-1alpha antibodies, and IL-1alpha depletion by RNA interference all markedly reduced senescence-associated IL-6/IL-8 secretion |
| 15388329 | Here, we show that in mouse embryonic fibroblasts (MEFs) culture in vitro, expression of an inflammatory cytokine, interleukin-1beta (IL-1beta) and its antagonist, IL-1 receptor antagonist (IL-1Ra) are induced by senescence |
| 15388329 | We also found a distinguishable accelerated senescence in cell growth in IL-1Ra deficient MEFs culture |
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