HCSGD entry for IKBKB
1. General information
| Official gene symbol | IKBKB |
|---|---|
| Entrez ID | 3551 |
| Gene full name | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
| Other gene symbols | IKK-beta IKK2 IKKB NFKBIKB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001782 | B cell homeostasis | IEA | biological_process |
| GO:0002224 | Toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0004672 | Protein kinase activity | IDA IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA NAS | biological_process |
| GO:0006954 | Inflammatory response | TAS | biological_process |
| GO:0007249 | I-kappaB kinase/NF-kappaB signaling | TAS | biological_process |
| GO:0007252 | I-kappaB phosphorylation | TAS | biological_process |
| GO:0008384 | IkappaB kinase activity | IEA TAS | molecular_function |
| GO:0008385 | IkappaB kinase complex | TAS | cellular_component |
| GO:0009615 | Response to virus | TAS | biological_process |
| GO:0009898 | Cytoplasmic side of plasma membrane | ISS | cellular_component |
| GO:0010765 | Positive regulation of sodium ion transport | IEA | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0032481 | Positive regulation of type I interferon production | TAS | biological_process |
| GO:0034134 | Toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0034138 | Toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0034142 | Toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0034146 | Toll-like receptor 5 signaling pathway | TAS | biological_process |
| GO:0034162 | Toll-like receptor 9 signaling pathway | TAS | biological_process |
| GO:0034166 | Toll-like receptor 10 signaling pathway | TAS | biological_process |
| GO:0035631 | CD40 receptor complex | ISS | cellular_component |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0035872 | Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | TAS | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0038123 | Toll-like receptor TLR1:TLR2 signaling pathway | TAS | biological_process |
| GO:0038124 | Toll-like receptor TLR6:TLR2 signaling pathway | TAS | biological_process |
| GO:0042501 | Serine phosphorylation of STAT protein | IDA | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043066 | Negative regulation of apoptotic process | TAS | biological_process |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045121 | Membrane raft | IEA | cellular_component |
| GO:0045893 | Positive regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IDA | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0050852 | T cell receptor signaling pathway | TAS | biological_process |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | IDA TAS | biological_process |
| GO:0070423 | Nucleotide-binding oligomerization domain containing signaling pathway | TAS | biological_process |
| GO:0071356 | Cellular response to tumor necrosis factor | IDA | biological_process |
| GO:2001259 | Positive regulation of cation channel activity | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1318051366 | 0.8654269595 | 0.7365794480 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3054427447 |
| GSE13712_SHEAR | Up | 0.2385707679 |
| GSE13712_STATIC | Down | -0.0244699626 |
| GSE19018 | Down | -0.0545255611 |
| GSE19899_A1 | Down | -0.1132001819 |
| GSE19899_A2 | Up | 0.1552616602 |
| PubMed_21979375_A1 | Up | 0.2611493728 |
| PubMed_21979375_A2 | Up | 0.1648918239 |
| GSE35957 | Up | 0.4004641305 |
| GSE36640 | Up | 0.3654144870 |
| GSE54402 | Down | -0.2929983615 |
| GSE9593 | Up | 0.5457976001 |
| GSE43922 | Up | 0.0958827393 |
| GSE24585 | Down | -0.3508507724 |
| GSE37065 | Up | 0.2165582153 |
| GSE28863_A1 | Up | 0.1066266598 |
| GSE28863_A2 | Up | 0.4604301773 |
| GSE28863_A3 | Down | -0.0317727159 |
| GSE28863_A4 | Down | -0.1180348772 |
| GSE48662 | Down | -0.0446932109 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Entries Per Page
Displaying Page of
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-199a-5p | MIMAT0000231 | MIRT003828 | Reporter assay//Western blot//GFP reporter assay//Luciferase reporter assay//qRT-PCR | Functional MTI | 18408758 |
| hsa-miR-218-5p | MIMAT0000275 | MIRT004030 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20933503 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT006884 | Luciferase reporter assay//Western blot | Functional MTI | 22569286 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018148 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-151a-3p | MIMAT0000757 | MIRT043610 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-196a-5p | MIMAT0000226 | 3 | hsa-miR-196a | {Western blot} | {overexpression by miRNA precursor transfection} | 18408758 | |
| hsa-miR-196a-5p | MIMAT0000226 | 2 | hsa-miR-196a | {Western blot} | {overexpression by miRNA precursor transfection} | 18408758 | |
| hsa-miR-196a-5p | MIMAT0000226 | 1 | hsa-miR-196a | {Western blot} | {overexpression by miRNA precursor transfection} | 18408758 |
Entries Per Page
Displaying Page of
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25699017 | These gene products include mTOR, IKK-beta/NF-kappaB complex, and HIF-1alpha, an important cellular survival signal |
| 25255445 | The classical (or canonical) pathway typically leads to the induction of RelA or c-Rel containing complexes, and involves the degradation of IkappaBalpha in a manner dependent on IkappaB kinase (IKK) beta and the IKK regulatory subunit NEMO |
| 24801508 | IL1beta acts intracranially inducing IKKbeta signaling, a mechanism that via nuclear factor-kappaB upregulates the expression of IL1beta itself |
| 24801508 | This latter event, together with enhanced IKKbeta signaling, increases TORC1 activity, thereby impairing the autophagic flux and inhibiting the phosphorylation of Akt and cAMP response element-binding protein |
| 22740410 | In contrast, although IKKbeta knockdown attenuated Tax-induced NF-kappaB transcriptional activation, the residual NF-kappaB activation in IKKbeta-deficient cells was sufficient to trigger Tax-IRS |
| 20937593 | Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma via inhibition of IKKbeta protein of the NFkappaB pathway |
| 20937593 | Reduced expression of cyclin D1, IkappaBalpha, phospho-IkappaBalpha, and IKKbeta occurred in cisplatin- and curcumin-treated cell lines |
| 20937593 | Confocal microscopy showed expression of IKKbeta in the nucleus of the cell lines |
| 20937593 | Chromatin immunoprecipitation assay on DNA isolated from IKKbeta immunoprecipitated samples showed PCR amplification of interleukin-8 promoter sequences, a binding site of NFkappaB, indicating an interaction between IKKbeta and NFkappaB |
| 20937593 | Curcumin inhibited IKKbeta in the cytoplasm and nucleus, leading to reduced NFkappaB activity, with no effect on phospho-AKT |
| 20937593 | The suppressive effect of curcumin was mediated through inhibition of cytoplasmic and nuclear IKKbeta, resulting in inhibition of NFkappaB activity |
Entries Per Page
Displaying Page of
