HCSGD entry for APRT
1. General information
| Official gene symbol | APRT |
|---|---|
| Entrez ID | 353 |
| Gene full name | adenine phosphoribosyltransferase |
| Other gene symbols | AMP APRTD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002055 | Adenine binding | IEA | molecular_function |
| GO:0003999 | Adenine phosphoribosyltransferase activity | IEA TAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006144 | Purine nucleobase metabolic process | TAS | biological_process |
| GO:0006166 | Purine ribonucleoside salvage | IEA | biological_process |
| GO:0006168 | Adenine salvage | IEA | biological_process |
| GO:0007595 | Lactation | IEA | biological_process |
| GO:0007625 | Grooming behavior | IEA | biological_process |
| GO:0009116 | Nucleoside metabolic process | IEA | biological_process |
| GO:0016208 | AMP binding | IDA IEA | molecular_function |
| GO:0016740 | Transferase activity | IEA | molecular_function |
| GO:0032869 | Cellular response to insulin stimulus | IEA | biological_process |
| GO:0043101 | Purine-containing compound salvage | TAS | biological_process |
| GO:0044209 | AMP salvage | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0196859124 | 0.6784593480 | 0.3412990190 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1559756779 |
| GSE13712_SHEAR | Down | -0.0792747528 |
| GSE13712_STATIC | Down | -0.0391223748 |
| GSE19018 | Up | 0.5459214867 |
| GSE19899_A1 | Up | 0.6661465378 |
| GSE19899_A2 | Up | 0.7516949061 |
| PubMed_21979375_A1 | Up | 1.9810424679 |
| PubMed_21979375_A2 | Up | 0.8108862327 |
| GSE35957 | Down | -0.2027549615 |
| GSE36640 | Up | 0.6183675262 |
| GSE54402 | Up | 0.5674500417 |
| GSE9593 | Up | 0.1964954859 |
| GSE43922 | Up | 0.2758564138 |
| GSE24585 | Down | -0.8753288358 |
| GSE37065 | Down | -0.2041051130 |
| GSE28863_A1 | Down | -0.1688347670 |
| GSE28863_A2 | Down | -0.0623153191 |
| GSE28863_A3 | Up | 0.1491699952 |
| GSE28863_A4 | Up | 0.0620275705 |
| GSE48662 | Down | -0.4038558060 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adenine | DB00173 | NUTR00012 | EXPT00520 |
| Alpha-Phosphoribosylpyrophosphoric Acid | DB01632 | EXPT02663 |
| 9-Deazaadenine | DB03506 | EXPT00355 |
| Citric Acid | DB04272 | EXPT00922 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT032354 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-484 | MIMAT0002174 | MIRT042286 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042963 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046502 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047618 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
