HCSGD entry for APOH

1. General information

Official gene symbolAPOH
Entrez ID350
Gene full nameapolipoprotein H (beta-2-glycoprotein I)
Other gene symbolsB2G1 B2GP1 BG
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001937Negative regulation of endothelial cell proliferationIDAbiological_process
GO:0001948Glycoprotein bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005543Phospholipid bindingIDAmolecular_function
GO:0005615Extracellular spaceIDA IEAcellular_component
GO:0006641Triglyceride metabolic processIDAbiological_process
GO:0007597Blood coagulation, intrinsic pathwayIDAbiological_process
GO:0008201Heparin bindingIEAmolecular_function
GO:0008289Lipid bindingIDAmolecular_function
GO:0009986Cell surfaceIDAcellular_component
GO:0010596Negative regulation of endothelial cell migrationIDAbiological_process
GO:0016525Negative regulation of angiogenesisIDAbiological_process
GO:0030193Regulation of blood coagulationIEAbiological_process
GO:0030194Positive regulation of blood coagulationTASbiological_process
GO:0030195Negative regulation of blood coagulationIDAbiological_process
GO:0031012Extracellular matrixIDAcellular_component
GO:0031639Plasminogen activationIDAbiological_process
GO:0033033Negative regulation of myeloid cell apoptotic processIDAbiological_process
GO:0034197Triglyceride transportISSbiological_process
GO:0034361Very-low-density lipoprotein particleIDAcellular_component
GO:0034364High-density lipoprotein particleIDAcellular_component
GO:0034392Negative regulation of smooth muscle cell apoptotic processIDAbiological_process
GO:0042627ChylomicronIDAcellular_component
GO:0042802Identical protein bindingIPImolecular_function
GO:0051006Positive regulation of lipoprotein lipase activityIDAbiological_process
GO:0051917Regulation of fibrinolysisIDAbiological_process
GO:0051918Negative regulation of fibrinolysisIDAbiological_process
GO:0060230Lipoprotein lipase activator activityIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74983465670.85318293760.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0396199968
GSE13712_SHEARUp0.0097413194
GSE13712_STATICUp0.1172827526
GSE19018Up0.1742277455
GSE19899_A1Up0.1029946362
GSE19899_A2Up0.0096646420
PubMed_21979375_A1Up0.1866204984
PubMed_21979375_A2Down-0.0506535809
GSE35957Up0.2410667976
GSE36640Up0.1180433798
GSE54402Down-0.0586253366
GSE9593Up0.0663549067
GSE43922Up0.0133152163
GSE24585Down-0.1044388353
GSE37065Down-0.0671436907
GSE28863_A1Down-0.0717429472
GSE28863_A2Down-0.0599991006
GSE28863_A3Up0.0739154973
GSE28863_A4Down-0.0482878101
GSE48662Down-0.0103353402

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL352039CHEMBL28598P02749
CHEMBL98858CHEMBL28598P02749
CHEMBL98472CHEMBL28598P02749
CHEMBL432306CHEMBL28598P02749
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  • Drugs

Name

Drug

Accession number

LJP 1082DB05446 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017373MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

15095782Exposure of phosphatidylserine is not a primary signal for RBC removal and where exposed it initiates binding of CRP or of beta-2-glycoprotein I and NAbs
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