HCSGD entry for CYR61

1. General information

Official gene symbolCYR61
Entrez ID3491
Gene full namecysteine-rich, angiogenic inducer, 61
Other gene symbolsCCN1 GIG1 IGFBP10
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001558Regulation of cell growthIEAbiological_process
GO:0001649Osteoblast differentiationIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIDAbiological_process
GO:0002041Intussusceptive angiogenesisIEAbiological_process
GO:0003181Atrioventricular valve morphogenesisIEAbiological_process
GO:0003278Apoptotic process involved in heart morphogenesisIEAbiological_process
GO:0003281Ventricular septum developmentIEAbiological_process
GO:0005178Integrin bindingIEAmolecular_function
GO:0005520Insulin-like growth factor bindingIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0006935ChemotaxisIEAbiological_process
GO:0008201Heparin bindingIEAmolecular_function
GO:0008283Cell proliferationTASbiological_process
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0010518Positive regulation of phospholipase activityIEAbiological_process
GO:0010811Positive regulation of cell-substrate adhesionIEAbiological_process
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIGIbiological_process
GO:0033690Positive regulation of osteoblast proliferationIDAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0044319Wound healing, spreading of cellsIDAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIDAbiological_process
GO:0045860Positive regulation of protein kinase activityIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0050840Extracellular matrix bindingIEAmolecular_function
GO:0060413Atrial septum morphogenesisIEAbiological_process
GO:0060591Chondroblast differentiationIEAbiological_process
GO:0060710Chorio-allantoic fusionIEAbiological_process
GO:0060716Labyrinthine layer blood vessel developmentIEAbiological_process
GO:0061036Positive regulation of cartilage developmentIEAbiological_process
GO:0070372Regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0072593Reactive oxygen species metabolic processIEAbiological_process
GO:2000304Positive regulation of ceramide biosynthetic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92994178410.00095267280.99999024730.0581263889

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.8912914176
GSE13712_SHEARUp0.8009950172
GSE13712_STATICUp0.0308891729
GSE19018Up0.1388939234
GSE19899_A1Down-1.9129725177
GSE19899_A2Down-1.2759418258
PubMed_21979375_A1Down-1.9007137150
PubMed_21979375_A2Down-2.5654327958
GSE35957Up0.1525403826
GSE36640Down-0.0408694451
GSE54402Down-1.8528668296
GSE9593Up0.3623341115
GSE43922Down-1.6193787837
GSE24585Up0.0471157313
GSE37065Down-0.7026432950
GSE28863_A1Up0.0038795994
GSE28863_A2Up0.1017312945
GSE28863_A3Up0.0747856581
GSE28863_A4Down-0.3963051333
GSE48662Down-0.6865531693

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-3pMIMAT0000088MIRT001764Luciferase reporter assay//qRT-PCR//Western blot//Western blot;qRT-PCRFunctional MTI16239240
hsa-miR-155-5pMIMAT0000646MIRT005484Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20452491
hsa-miR-155-5pMIMAT0000646MIRT005484ProteomicsFunctional MTI (Weak)18668040
hsa-miR-205-5pMIMAT0000266MIRT006935Western blotFunctional MTI23056551
hsa-miR-124-3pMIMAT0000422MIRT023099MicroarrayFunctional MTI (Weak)18668037
hsa-miR-26b-5pMIMAT0000083MIRT030115MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-155-5pMIMAT0000646NAhsa-miR-155{Western blot}{endogenous}20452491
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19563823In contrast, some other genes, including DUSP6, CYR61, and F3, showed sustained upregulation in senescent HDFs later after LPA treatment
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