HCSGD entry for GEN1
1. General information
| Official gene symbol | GEN1 |
|---|---|
| Entrez ID | 348654 |
| Gene full name | GEN1 Holliday junction 5' flap endonuclease |
| Other gene symbols | Gen |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004518 | Nuclease activity | IEA | molecular_function |
| GO:0004519 | Endonuclease activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9938380685 | 0.0009466358 | 0.9999902473 | 0.0579451163 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3161755388 |
| GSE13712_SHEAR | Up | 0.0824317690 |
| GSE13712_STATIC | Down | -0.1333223067 |
| GSE19018 | Down | -0.7163480460 |
| GSE19899_A1 | Down | -0.2332762838 |
| GSE19899_A2 | Down | -1.2709289104 |
| PubMed_21979375_A1 | Down | -1.0207471049 |
| PubMed_21979375_A2 | Down | -0.7550372366 |
| GSE35957 | Down | -0.8021646334 |
| GSE36640 | Down | -2.4257252181 |
| GSE54402 | Down | -0.1948443858 |
| GSE9593 | Down | -0.6440073070 |
| GSE43922 | Down | -0.5278400082 |
| GSE24585 | Down | -0.4574882459 |
| GSE37065 | Down | -0.0024522857 |
| GSE28863_A1 | Down | -0.4481770087 |
| GSE28863_A2 | Up | 0.7502129683 |
| GSE28863_A3 | Down | -0.9430901421 |
| GSE28863_A4 | Down | -0.1109432389 |
| GSE48662 | Down | -0.4753581378 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024641 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026735 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
