HCSGD entry for IGF2

1. General information

Official gene symbolIGF2
Entrez ID3481
Gene full nameinsulin-like growth factor 2 (somatomedin A)
Other gene symbolsC11orf43 IGF-II PP9974
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentTASbiological_process
GO:0001503OssificationIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationISSbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0005158Insulin receptor bindingIPImolecular_function
GO:0005159Insulin-like growth factor receptor bindingTASmolecular_function
GO:0005179Hormone activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006006Glucose metabolic processIEAbiological_process
GO:0006349Regulation of gene expression by genetic imprintingTASbiological_process
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008083Growth factor activityIDAmolecular_function
GO:0008284Positive regulation of cell proliferationICbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0010469Regulation of receptor activityISSbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030546Receptor activator activityISSmolecular_function
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0038028Insulin receptor signaling pathway via phosphatidylinositol 3-kinaseISSbiological_process
GO:0042104Positive regulation of activated T cell proliferationIDAbiological_process
GO:0043085Positive regulation of catalytic activityISSbiological_process
GO:0043410Positive regulation of MAPK cascadeIDAbiological_process
GO:0043539Protein serine/threonine kinase activator activityISSmolecular_function
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045725Positive regulation of glycogen biosynthetic processISSbiological_process
GO:0045840Positive regulation of mitosisIDAbiological_process
GO:0045859Regulation of protein kinase activityISSbiological_process
GO:0045860Positive regulation of protein kinase activityISSbiological_process
GO:0046628Positive regulation of insulin receptor signaling pathwayIDAbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationISSbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIDAbiological_process
GO:0071902Positive regulation of protein serine/threonine kinase activityISSbiological_process
GO:2000273Positive regulation of receptor activityISSbiological_process
GO:2000467Positive regulation of glycogen (starch) synthase activityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01395935560.99815290070.29370439651.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.0503775552
GSE28863_A2Up0.3575505416
GSE28863_A3Up0.4677017186
GSE28863_A4Up0.4973341266
GSE48662Up0.7146526079

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7a-5pMIMAT0000062MIRT004520Luciferase reporter assayFunctional MTI17974952
hsa-miR-125b-5pMIMAT0000423MIRT005738Luciferase reporter assay//Northern blot//Western blotFunctional MTI21200031
hsa-miR-150-5pMIMAT0000451MIRT005739Luciferase reporter assayNon-Functional MTI21200031
hsa-miR-615-5pMIMAT0004804MIRT007015Luciferase reporter assayFunctional MTI22819824
hsa-miR-877-5pMIMAT0004949MIRT037339CLASHFunctional MTI (Weak)23622248
hsa-miR-93-5pMIMAT0000093MIRT048842CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20622962Downregulated genes included cyclin D2, keratin 8, insulin-like growth factor 2 (IGF2), natriuretic peptide precursor B (NPPB) and cellular retinoic acid binding protein 2 (CRABP2)
20622962The expression pattern of the selected genes was consistent with the microarray data except for CXCL12 and IGF2
20364576OBJECTIVE: Epigenetic regulations of insulin-like growth factor 2 (IGF2) were observed during cellular replicative senescence and premature senescence induced by hydrogen peroxide of human embryonic lung fibroblasts (HEFs)
20364576METHODS: The mRNA level of IGF2 was detected by Q-PCR
20364576RESULTS: In the process of cellular senescence, the mRNA level of IGF2 increased in both mid-aged and replicative senescent cells, but increased obviously in premature senescent cells compared with that of young cells
20364576In the promotor region from -658 bp to -456 bp, the methylation level for IGF2 was detected only in replicative senescent cells
20364576About the main histone modifications, IGF2 in the region (-856 bp - -634 bp) was H4 acetylation and H3K4 methylation in replicative senescence, while in the region (+9 bp - +145 bp) was H3K4 and H4K20 methylation in replicative senescence and H3K4 methylation in premature senescence
21994573Finally, antiproliferative and apoptosis deficiencies involving TGF-beta, Akt/PTEN, IGF2 pathways for instance are prerequisite for cancerous transformation
15471867The imprinted insulin-like growth factor-2 (IGF2) gene is an auto/paracrine growth factor expressed only from the paternal allele in adult tissues
15471867In tissues susceptible to aging-related cancers, including the prostate, a relaxation of IGF2 imprinting is found, suggesting a permissive role for epigenetic alterations in cancer development
15471867To determine whether IGF2 imprinting is altered in cellular aging and senescence, human prostate epithelial and urothelial cells were passaged serially in culture to senescence
15471867Allelic analyses using an IGF2 polymorphism demonstrated a complete conversion of the IGF2 imprint status from monoallelic to biallelic, in which the development of senescence was associated with a 10-fold increase in IGF2 expression
15471867As a mechanism, a 2-fold decrease in the binding of the enhancer-blocking element CCCTC-binding factor (CTCF) within the intergenic IGF2-H19 region was found to underlie this switch to biallelic IGF2 expression in senescent cells
15471867No de novo increases in methylation at the IGF2 CTCF binding site were seen
15471867The forced down-regulation of CTCF expression using small interfering RNA in imprinted prostate cell lines resulted in an increase in IGF2 expression and a relaxation of imprinting
15471867Our data suggest a novel mechanism for IGF2 imprinting regulation, that is, the reduction of CTCF expression in the control of IGF2 imprinting
1701724Changes in expression of various genes, including those encoding mitogen-regulated protein (proliferin), endogenous gag-pol retrovirus sequences, insulin-like growth factor II, and a variety of protooncogenes, were monitored during the process of immortalization, and although certain changes were reproducibly characteristic of cells from a given mouse strain passed according to a specific regimen, none of the observed changes were reproducibly characteristic under all conditions of immortalization
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