HCSGD entry for IFNAR1

1. General information

Official gene symbolIFNAR1
Entrez ID3454
Gene full nameinterferon (alpha, beta and omega) receptor 1
Other gene symbolsAVP IFN-alpha-REC IFNAR IFNBR IFRC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004904Interferon receptor activityIEAmolecular_function
GO:0004905Type I interferon receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0009615Response to virusTASbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0032729Positive regulation of interferon-gamma productionIEAbiological_process
GO:0042110T cell activationIEAbiological_process
GO:0045351Type I interferon biosynthetic processIEAbiological_process
GO:0051607Defense response to virusIEAbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0060338Regulation of type I interferon-mediated signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02764306070.99287412710.38578632031.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0784722094
GSE13712_SHEARUp0.0897869721
GSE13712_STATICDown-0.0027894933
GSE19018Up0.0444511721
GSE19899_A1Up0.0127575025
GSE19899_A2Up0.3503986561
PubMed_21979375_A1Up0.3937538267
PubMed_21979375_A2Up0.2902955729
GSE35957Up0.3397244903
GSE36640Up0.8663721550
GSE54402Down-0.0241558867
GSE9593Up0.3294686351
GSE43922Up0.4098074991
GSE24585Up0.3534870392
GSE37065Up0.0982962868
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.4141017373

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Peginterferon alfa-2aDB00008 BTD00043 | BIOD00043
Interferon alfa-n1DB00011 BTD00096 | BIOD00096 | DB00084
Interferon alfa-n3DB00018 BTD00023 | BIOD00023
Peginterferon alfa-2bDB00022 BTD00048 | BIOD00048
Interferon beta-1aDB00060 BTD00093 | BIOD00093
Interferon beta-1bDB00068 BTD00078 | BIOD00078
Interferon alfacon-1DB00069 BTD00062 | BIOD00062
Interferon Alfa-2b, RecombinantDB00105 BTD00066 | BIOD00066
Natural alpha interferonDB05258 -
omega interferonDB05472 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-98-5pMIMAT0000096MIRT027659MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27052162Inactivation of the IFN pathway is mediated by the IFN receptor IFNAR1 downregulation that invariably occurs during melanoma development
27052162These results suggest that IFN signaling is an important tumor-suppressive pathway that inhibits melanoma development and progression and argue for targeting IFNAR1 downregulation to prevent metastatic disease and improve the efficacy of molecularly target and immune-targeted melanoma therapies
26046815Furthermore, neutralization of endogenous IFN or genetic ablation of its receptor chain IFNAR1 compromises the recognition of senescent cells and their clearance in vitro and in vivo
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