HCSGD entry for APOC3

1. General information

Official gene symbolAPOC3
Entrez ID345
Gene full nameapolipoprotein C-III
Other gene symbolsAPOCIII HALP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001523Retinoid metabolic processTASbiological_process
GO:0005543Phospholipid bindingIDAmolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIDA IEAcellular_component
GO:0005769Early endosomeTAScellular_component
GO:0006641Triglyceride metabolic processIMPbiological_process
GO:0006642Triglyceride mobilizationIEAbiological_process
GO:0006869Lipid transportIEAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0008289Lipid bindingIEAmolecular_function
GO:0010897Negative regulation of triglyceride catabolic processIDAbiological_process
GO:0010903Negative regulation of very-low-density lipoprotein particle remodelingIC IDAbiological_process
GO:0010916Negative regulation of very-low-density lipoprotein particle clearanceIDAbiological_process
GO:0010987Negative regulation of high-density lipoprotein particle clearanceIMPbiological_process
GO:0010989Negative regulation of low-density lipoprotein particle clearanceIMPbiological_process
GO:0015485Cholesterol bindingICmolecular_function
GO:0019433Triglyceride catabolic processIDA IEAbiological_process
GO:0030234Enzyme regulator activityIDAmolecular_function
GO:0032489Regulation of Cdc42 protein signal transductionIDAbiological_process
GO:0033344Cholesterol effluxIDAbiological_process
GO:0033700Phospholipid effluxIDAbiological_process
GO:0034361Very-low-density lipoprotein particleIDAcellular_component
GO:0034363Intermediate-density lipoprotein particleIDAcellular_component
GO:0034366Spherical high-density lipoprotein particleIDAcellular_component
GO:0034375High-density lipoprotein particle remodelingIMPbiological_process
GO:0034379Very-low-density lipoprotein particle assemblyTASbiological_process
GO:0034382Chylomicron remnant clearanceIDAbiological_process
GO:0042157Lipoprotein metabolic processIEA TASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042627ChylomicronIDAcellular_component
GO:0042632Cholesterol homeostasisIMPbiological_process
GO:0042953Lipoprotein transportIEAbiological_process
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0043691Reverse cholesterol transportICbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045717Negative regulation of fatty acid biosynthetic processIDAbiological_process
GO:0045833Negative regulation of lipid metabolic processIDAbiological_process
GO:0048261Negative regulation of receptor-mediated endocytosisIDAbiological_process
GO:0050995Negative regulation of lipid catabolic processIDAbiological_process
GO:0051005Negative regulation of lipoprotein lipase activityIDAbiological_process
GO:0055102Lipase inhibitor activityIDAmolecular_function
GO:0060621Negative regulation of cholesterol importIMPbiological_process
GO:0070328Triglyceride homeostasisIMPbiological_process
GO:0070653High-density lipoprotein particle receptor bindingIPImolecular_function
GO:0071333Cellular response to glucose stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.69314157520.75325707990.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1086686790
GSE13712_SHEARUp0.0685104043
GSE13712_STATICDown-0.1603692222
GSE19018Up0.0139071174
GSE19899_A1Up0.0735041841
GSE19899_A2Down-0.0427741106
PubMed_21979375_A1Up0.0095993754
PubMed_21979375_A2Up0.2135369531
GSE35957Up0.1211473263
GSE36640Down-0.0220688807
GSE54402Down-0.0293004276
GSE9593Down-0.2817021383
GSE43922Up0.0605396241
GSE24585Up0.0921839523
GSE37065Down-0.0786058161
GSE28863_A1Up0.1607376348
GSE28863_A2Down-0.1862382501
GSE28863_A3Up0.2706047106
GSE28863_A4Up0.1366954765
GSE48662Down-0.0415127629

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.