HCSGD entry for IDH2
1. General information
| Official gene symbol | IDH2 |
|---|---|
| Entrez ID | 3418 |
| Gene full name | isocitrate dehydrogenase 2 (NADP+), mitochondrial |
| Other gene symbols | D2HGA2 ICD-M IDH IDHM IDP IDPM mNADP-IDH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IEA ISS | molecular_function |
| GO:0004450 | Isocitrate dehydrogenase (NADP+) activity | EXP IEA ISS | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | NAS | biological_process |
| GO:0006097 | Glyoxylate cycle | IEA | biological_process |
| GO:0006099 | Tricarboxylic acid cycle | IEA TAS | biological_process |
| GO:0006102 | Isocitrate metabolic process | IEA ISS | biological_process |
| GO:0006103 | 2-oxoglutarate metabolic process | ISS | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0051287 | NAD binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9523398047 | 0.0005805099 | 0.9999902473 | 0.0452772189 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.2671628003 |
| GSE13712_SHEAR | Down | -0.9651416503 |
| GSE13712_STATIC | Down | -0.7376686522 |
| GSE19018 | Down | -0.0349175597 |
| GSE19899_A1 | Down | -1.2522940358 |
| GSE19899_A2 | Down | -1.8248790367 |
| PubMed_21979375_A1 | Down | -1.8412611930 |
| PubMed_21979375_A2 | Down | -2.7113558479 |
| GSE35957 | Down | -0.1689747115 |
| GSE36640 | Down | -1.5884690417 |
| GSE54402 | Down | -0.0765979465 |
| GSE9593 | Down | -0.6818824027 |
| GSE43922 | Down | -1.4017152206 |
| GSE24585 | Up | 0.7078287746 |
| GSE37065 | Down | -0.7430334415 |
| GSE28863_A1 | Up | 0.1224833020 |
| GSE28863_A2 | Up | 0.1157191770 |
| GSE28863_A3 | Up | 0.2482050833 |
| GSE28863_A4 | Down | -0.0310725760 |
| GSE48662 | Down | -0.3009894622 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Isocitric Acid | DB01727 | EXPT01834 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-183-5p | MIMAT0000261 | MIRT007339 | Immunocytochemistry//Luciferase reporter assay//qRT-PCR | Functional MTI | 23263745 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029275 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052706 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
