HCSGD entry for APOC1

1. General information

Official gene symbolAPOC1
Entrez ID341
Gene full nameapolipoprotein C-I
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004859Phospholipase inhibitor activityIDAmolecular_function
GO:0005504Fatty acid bindingIDAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0006629Lipid metabolic processTASbiological_process
GO:0006641Triglyceride metabolic processIEAbiological_process
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0010873Positive regulation of cholesterol esterificationTASbiological_process
GO:0010900Negative regulation of phosphatidylcholine catabolic processIDAbiological_process
GO:0010916Negative regulation of very-low-density lipoprotein particle clearanceIDAbiological_process
GO:0031210Phosphatidylcholine bindingTASmolecular_function
GO:0032374Regulation of cholesterol transportICbiological_process
GO:0032375Negative regulation of cholesterol transportIDAbiological_process
GO:0033344Cholesterol effluxIDAbiological_process
GO:0033700Phospholipid effluxIDAbiological_process
GO:0034361Very-low-density lipoprotein particleIDAcellular_component
GO:0034364High-density lipoprotein particleIDAcellular_component
GO:0034369Plasma lipoprotein particle remodelingIDAbiological_process
GO:0034375High-density lipoprotein particle remodelingTASbiological_process
GO:0034379Very-low-density lipoprotein particle assemblyTASbiological_process
GO:0034382Chylomicron remnant clearanceIDAbiological_process
GO:0034447Very-low-density lipoprotein particle clearanceIGIbiological_process
GO:0042157Lipoprotein metabolic processIEAbiological_process
GO:0042627ChylomicronTAScellular_component
GO:0043085Positive regulation of catalytic activityTASbiological_process
GO:0045717Negative regulation of fatty acid biosynthetic processIDAbiological_process
GO:0045833Negative regulation of lipid metabolic processIDAbiological_process
GO:0048261Negative regulation of receptor-mediated endocytosisIDAbiological_process
GO:0050995Negative regulation of lipid catabolic processIDAbiological_process
GO:0051005Negative regulation of lipoprotein lipase activityIDAbiological_process
GO:0055102Lipase inhibitor activityIDAmolecular_function
GO:0060228Phosphatidylcholine-sterol O-acyltransferase activator activityTASmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.87976210250.12194922310.99999024730.6700586358

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0888055028
GSE13712_SHEARUp0.0198501937
GSE13712_STATICUp0.0181043438
GSE19018Down-0.2944929800
GSE19899_A1Down-0.1175677384
GSE19899_A2Down-0.0726819428
PubMed_21979375_A1Down-0.0497357405
PubMed_21979375_A2Down-0.1919098676
GSE35957Down-0.2132788883
GSE36640Down-0.2069143539
GSE54402Down-0.0938584295
GSE9593Down-1.5450024150
GSE43922Down-0.1079464647
GSE24585Up0.2429179409
GSE37065Up0.0727913816
GSE28863_A1Up0.2152609566
GSE28863_A2Down-0.0770265308
GSE28863_A3Up0.3744324609
GSE28863_A4Up0.1329106074
GSE48662Down-0.3912077249

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018338MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.