HCSGD entry for TMEM173

1. General information

Official gene symbolTMEM173
Entrez ID340061
Gene full nametransmembrane protein 173
Other gene symbolsERIS MITA MPYS NET23 STING
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002218Activation of innate immune responseIEA IMPbiological_process
GO:0002230Positive regulation of defense response to virus by hostIMPbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005741Mitochondrial outer membraneIDAcellular_component
GO:0005777PeroxisomeIEAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005789Endoplasmic reticulum membraneIDA TAScellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0008134Transcription factor bindingIDAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0019901Protein kinase bindingIDA IPImolecular_function
GO:0030659Cytoplasmic vesicle membraneTAScellular_component
GO:0031625Ubiquitin protein ligase bindingIEAmolecular_function
GO:0032092Positive regulation of protein bindingIDAbiological_process
GO:0032479Regulation of type I interferon productionTASbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0032608Interferon-beta productionIDA IMPbiological_process
GO:0033160Positive regulation of protein import into nucleus, translocationIDAbiological_process
GO:0035438Cyclic-di-GMP bindingIDA IEAmolecular_function
GO:0035458Cellular response to interferon-betaIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0042993Positive regulation of transcription factor import into nucleusIDAbiological_process
GO:0045087Innate immune responseIDA IMP TASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0048471Perinuclear region of cytoplasmIEA ISScellular_component
GO:0051607Defense response to virusIDAbiological_process
GO:0061507Cyclic-GMP-AMP bindingIEA ISSmolecular_function
GO:0071360Cellular response to exogenous dsRNAIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18335889970.19684838340.83762136410.8586752237

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1733585039
GSE13712_SHEARDown-0.2726074999
GSE13712_STATICDown-0.5748330706
GSE19018Down-0.2251508381
GSE19899_A1Up0.1922992821
GSE19899_A2Up0.8568111671
PubMed_21979375_A1Up0.1583738400
PubMed_21979375_A2Up0.6257007353
GSE35957Up0.1742777924
GSE36640Up0.6656526917
GSE54402Up0.2698644022
GSE9593Down-0.0262844382
GSE43922Down-0.0689736219
GSE24585Up0.3636764314
GSE37065Down-0.0251042959
GSE28863_A1Up0.0287240508
GSE28863_A2Down-0.0005719831
GSE28863_A3Down-0.7162662934
GSE28863_A4Down-0.1702149820
GSE48662Down-0.0967012846

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-25-3pMIMAT0000081MIRT050207CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.