HCSGD entry for TMPRSS11A
1. General information
| Official gene symbol | TMPRSS11A |
|---|---|
| Entrez ID | 339967 |
| Gene full name | transmembrane protease, serine 11A |
| Other gene symbols | ECRG1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7693244824 | 0.8823537100 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | Down | -0.0073559198 |
| GSE24585 | Down | -0.0432596494 |
| GSE37065 | Down | -0.0515411042 |
| GSE28863_A1 | Up | 0.0429548217 |
| GSE28863_A2 | Down | -0.1463957653 |
| GSE28863_A3 | Up | 0.1068323551 |
| GSE28863_A4 | Up | 0.1690348966 |
| GSE48662 | Up | 0.0416625409 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019407 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025177 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16380648 | ECRG1, a novel candidate of tumor suppressor gene in the esophageal carcinoma, triggers a senescent program in NIH3T3 cells |
| 16380648 | Esophageal cancer-related gene 1 (ECRG1) is a novel tumor-suppressor gene candidate identified from the human esophagus |
| 16380648 | Previous studies showed that ECRG1 overexpression could inhibit cell growth and induce G1 cell cycle arrest and p15(INK4b) expression by interacting with Miz-1 (Myc-interacting zinc finger protein) |
| 16380648 | Such evidence suggests the alterations in ECRG1 may play an important role in tumorigenesis |
| 16380648 | To further study the biological function of the ECRG1 gene, we transfected ECRG1 into NIH3T3 cells |
| 16380648 | Expression of ECRG1 in these cells caused senescence-like changes characterized in terms of altered cell morphology, cell cycle arrest at the G1/S phase, and significantly impaired cell proliferation (P < 0 |
| 16380648 | Moreover, NIH3T3 cells transfected with ECRG1 stained positive for SA-beta-gal staining (pH 6 |
| 16380648 | The results indicated that when ECRG1 induced a senescence-like state, telomerase activity was markedly decreased (P < 0 |
| 16380648 | These findings suggest that ECRG1 may be of importance in murine cell senescence, promoting senescence by regulating expression of p21 |
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