HCSGD entry for ID3

1. General information

Official gene symbolID3
Entrez ID3399
Gene full nameinhibitor of DNA binding 3, dominant negative helix-loop-helix protein
Other gene symbolsHEIR-1 bHLHb25
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001656Metanephros developmentIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003714Transcription corepressor activityTASmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006275Regulation of DNA replicationIEAbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0007417Central nervous system developmentIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0007517Muscle organ developmentIEAbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0009611Response to woundingIEAbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030182Neuron differentiationIEAbiological_process
GO:0030855Epithelial cell differentiationIEAbiological_process
GO:0030903Notochord developmentIEAbiological_process
GO:0042476OdontogenesisIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0045668Negative regulation of osteoblast differentiationIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0051726Regulation of cell cycleIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96621779190.00013090310.99999024730.0202052326

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.9251889967
GSE13712_SHEARUp0.8355363765
GSE13712_STATICUp0.0366669889
GSE19018Down-1.5785465737
GSE19899_A1Down-2.3997964192
GSE19899_A2Down-2.2889632687
PubMed_21979375_A1Down-1.2915101768
PubMed_21979375_A2Down-2.1743717363
GSE35957Down-0.0788968519
GSE36640Up0.1760983563
GSE54402Up0.2343299573
GSE9593Down-2.0192605523
GSE43922Down-1.0210965026
GSE24585Down-0.1304511651
GSE37065Down-0.1329866088
GSE28863_A1Up0.0059593577
GSE28863_A2Down-2.7808803867
GSE28863_A3Down-0.3192836527
GSE28863_A4Down-0.4879556857
GSE48662Up0.3580387618

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-520hMIMAT0002867MIRT004740Microarray//qRT-PCRFunctional MTI (Weak)19435428
hsa-miR-124-3pMIMAT0000422MIRT022266MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-125b-5pMIMAT0000423NAhsa-miR-125b18056640
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24122992In contrast to high Id1, Id2 and Id3 expression, the expression of Id4 is epigenetically silenced in prostate cancer
21933340Here, we report for the first time the identification of Smurf2 as the E3 ligase that ubiquitinates Id1 and Id3
21933340Smurf2-mediated ubiquitination and consequent degradation of Id1 or Id3 plays an important role in the regulation of Id expression in senescent cells
15659210Senescence was accompanied by a decline in transcript levels of the polycomb gene Bmi-1, Ets1 and Ets2 transcription factors, and Id1, Id2 and Id3 helix-loop-helix proteins, suggesting roles for these genes in maintenance of cardiomyocyte proliferative capacity
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